The NLRP3 inflammasome is cytosolic multi-protein complex that induces inflammation and
pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators …

Acute kidney injury (AKI) has been widely recognized as an important risk factor for the
occurrence and development of chronic kidney disease (CKD). Even milder AKI has adverse …

Contrast-induced acute kidney injury (CI-AKI) occurs in more than 30% of patients after
intravenous iodinated contrast media and causes serious complications, including renal …

The pathogenetic mechanism of contrast-induced acute kidney injury (CI-AKI), which is the
third most common cause of hospital-acquired AKI, has not been elucidated. Previously, we …

Efficient therapies for diabetic kidney disease (DKD), now the leading cause of kidney
failure, are lacking. One hallmark of DKD is sterile inflammation (inflammation in absence of …

Although fibrosis is a common pathological feature of most end-stage organ diseases, its
pathogenesis remains unclear. There is growing evidence that mitochondrial dysfunction …

Physical trauma can affect any individual and is globally accountable for more than one in
every ten deaths. Although direct severe kidney trauma is relatively infrequent, extrarenal …

Oxidative stress is a major contributor to the pathogenesis of various inflammatory diseases.
Accumulating evidence has shown that oxidative stress is characterized by the …

Cisplatin, as a commonly used anticancer drug, can easily lead to acute kidney injury (AKI),
and has received more and more attention in clinical practice. β-hydroxybutyric acid (BHB) is …

Chronic kidney disease affects approximately 14.3% of people worldwide. Tubulointerstitial
fibrosis is the final stage of almost all progressive CKD. To date, the pathogenesis of renal …