Background Primary lateral sclerosis (PLS) is traditionally solely associated with progressive
upper motor neuron dysfunction manifesting in limb spasticity, gait impairment, bulbar …

Although machine-learning (ML) approaches have been extensively utilized in
neurodegenerative conditions, they can be challenging to implement in motor neuron …

Primary lateral sclerosis and amyotrophic lateral sclerosis are primarily associated with
motor cortex and corticospinal tract pathology. A standardised, prospective, single-centre …

BACKGROUND AND PURPOSE: The previous studies described phenotype-associated
imaging findings in amyotrophic lateral sclerosis (ALS) with a prior categorization of patients …

The majority of radiology studies in neurodegenerative conditions infer group-level imaging
traits from group comparisons. While this strategy is helpful to define phenotype-specific …

Imaging studies of FTD typically present group-level statistics between large cohorts of
genetically, molecularly or clinically stratified patients. Group-level statistics are …

Following the exclusion of potentially reversible causes, the differential for those patients
presenting with a predominant upper motor neuron syndrome includes primary lateral …

A standardised imaging protocol was implemented to evaluate disease burden in specific
thalamic and amygdalar nuclei in 133 carefully phenotyped and genotyped motor neuron …

Primary lateral sclerosis (PLS) is a rare neurodegenerative disorder which causes the
selective deterioration of the upper motor neurons (UMNs), sparing the lower motor neuron …

Introduction Hereditary spastic paraplegias (HSP) include a clinically and genetically
heterogeneous group of conditions. Novel imaging modalities have been increasingly …