Human primordial germ cell-like cells specified from resetting precursors develop in human hindgut organoids
JP Alves-Lopes, FCK Wong, MA Surani - Nature Protocols, 2024 - nature.com
Human primordial germ cells (hPGCs), the precursors of eggs and sperm, start their complex
development shortly after specification and during their migration to the primitive gonads …
development shortly after specification and during their migration to the primitive gonads …
[HTML][HTML] Defining the cellular origin of seminoma by transcriptional and epigenetic mapping to the normal human germline
Aberrant male germline development can lead to the formation of seminoma, a testicular
germ cell tumor. Seminomas are biologically similar to primordial germ cells (PGCs) and …
germ cell tumor. Seminomas are biologically similar to primordial germ cells (PGCs) and …
Evidence of the ability of endocrine disrupting compounds to induce testicular germ cell cancer in humans.
N Nicolas Jr, D Moison, A Jampy Jr, N Dechamps… - bioRxiv, 2023 - biorxiv.org
Testicular cancer is an increasing burden in modern societies and the most common
malignancy among young adult males. Environment contaminants, especially endocrine …
malignancy among young adult males. Environment contaminants, especially endocrine …
Generation of spermatogonia from pluripotent stem cells in humans and non-human primates
Failures in germline development drive male infertility, but the lack of model systems that
recapitulate human spermatogenesis hampers therapeutic development. Here, we have …
recapitulate human spermatogenesis hampers therapeutic development. Here, we have …