Every year, a major cause of human disease and death worldwide is infection with the
various pathogens—viruses, bacteria, fungi, and protozoa—that are intrinsic to our …

Sporotrichosis is a mycosis that affects the skin, lymphatic system and other organs in
humans and animals. The disease has a worldwide distribution, with endemic areas in …

Chromatin is the assembly of genomic DNA and proteins packaged in the nucleus of
eukaryotic cells, which together are crucial in regulating a plethora of cellular processes …

Histone variants play a crucial role in chromatin structure organization and gene expression.
Trypanosomatids have an unusual H2B variant (H2B. V) that is known to dimerize with the …

Trypanosoma cruzi is a digenetic unicellular parasite that alternates between a blood-
sucking insect and a mammalian, host causing Chagas disease or American …

Background In the last decade, resistance to antimonials has become a serious problem
due to the emergence of drug-resistant strains. Therefore, understanding the mechanisms …

In trypanosomatids, transcription is polycistronic and all mRNAs are processed by trans-
splicing, with export mediated by noncanonical mechanisms. Although mRNA export is …

Chagas is an endemic disease in tropical regions of Latin America, caused by the parasite
Trypanosoma cruzi. High intraspecies variability and genome complexity have been …

The protozoan Trypanosoma cruzi is the causative agent of the neglected infectious illness
Chagas disease. During its life cycle it differentiates into replicative and non-replicative life …

Kinetoplastid parasites, included Trypanosoma cruzi, the causal agent of Chagas disease,
present a unique genome organization and gene expression. Although they control gene …