The interplay between signaling and trafficking by G protein–coupled receptors (GPCRs)
has focused mainly on endocytic trafficking. Whether and how surface delivery of newly …

The δ opioid receptor (δR) is a promising alternate target for pain management because δR
agonists show decreased abuse potential compared with current opioid analgesics that …

The Ca 2+ signals evoked by inositol 1, 4, 5-trisphosphate (IP 3) are built from elementary
Ca 2+ release events involving progressive recruitment of IP 3 receptors (IP 3 R) …

Inhibition of K-RAS effectors like B-RAF or MEK1/2 is accompanied by treatment resistance
in cancer patients via re-activation of PI3K and Wnt signaling. We hypothesised that …

Peroxisome proliferator-activated receptor-gamma (PPARγ) is a transcription factor drugable
by agonists approved for treatment of type 2 diabetes, but also inhibits carcinogenesis and …

Phosphatidylinositol phosphates (PIPs) and soluble inositol phosphates (IPs) serve as
critical secondary messenger molecules that regulate cellular processes. The INPP5 family …

The triad, formed by the close apposition of the T-tubule and terminal sarcoplasmic
reticulum, is an important skeletal muscle substructure that regulates excitation-contraction …

Der Kernrezeptor Peroxisom-Proliferator-aktivierter Rezeptor-γ (PPARγ) stellt einen
bedeutenden Faktor an der Schnittstelle zwischen Lebensstil, Metabolismus und …

Alzheimer's disease (AD) is the leading cause of dementia in the elderly. In countries with
aging populations, such as Australia, the prevalence of AD is projected to increase …

X-linked myotubular myopathy (MTM) is a severe centronuclear myopathy, characterized by
profound weakness and hypotonia at birth, early mortality, and significant morbidities. MTM …