Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …

The innate immune system is a primary protective line in our body. It confers its protection
through different pattern recognition receptors (PRRs), especially toll like receptors (TLRs) …

Antibiotic use in early life disrupts microbial colonization and increases the risk of
developing allergies and asthma. We report that mice given antibiotics in early life (EL-Abx) …

Background Experimental studies suggest that exposures may impact respiratory health
across generations via epigenetic changes transmitted specifically through male germ cells …

DNA methylation (DNAm) has been shown to play a role in mediating food allergy; however,
the mechanism by which it does so is poorly understood. In this study, we used targeted next …

Toll-like receptors of the human immune system are specialized pathogen detectors able to
link innate and adaptive immune responses. TLR ligands include among others bacteria …

Asthma is a common chronic inflammatory disease of the lungs and airway, yet its
inflammatory subtypes and potential pathogenesis have not been completely elucidated and …

Stimulator of interferon genes (STING) is a DNA sensor that responds to pathogens and
induces type I interferon production. Herein, the role of STING in house dust mite extract …

Abstract Background The interleukin-2 (IL-2) family of cytokines, including IL-2, IL-4, IL-7, IL-
9, IL-15, and IL-21, are pivotal regulators of the immune response, impacting both innate …

Mitochondrial dysfunction is common in various pathological conditions including obesity.
Release of mitochondrial DNA (mtDNA) during mitochondrial dysfunction has been shown …