Chemical roots of biological evolution: the origins of life as a process of development of autonomous functional systems

K Ruiz-Mirazo, C Briones… - Open biology, 2017 - royalsocietypublishing.org
In recent years, an extension of the Darwinian framework is being considered for the study of
prebiotic chemical evolution, shifting the attention from homogeneous populations of naked …

The origin of life: what we know, what we can know and what we will never know

A Pross, R Pascal - Open biology, 2013 - royalsocietypublishing.org
The origin of life (OOL) problem remains one of the more challenging scientific questions of
all time. In this essay, we propose that following recent experimental and theoretical …

A simple synthetic replicator amplifies itself from a dynamic reagent pool

JW Sadownik, D Philp - … Chemie-International Edition, 2008 - scholars.northwestern.edu
Abstract (Figure Presented) The fate of a dynamic combinatorial library is determined by
coupling the exchange processes to a synthetic replicator. The replicating template is …

Exploring the emergence of complexity using synthetic replicators

T Kosikova, D Philp - Chemical Society Reviews, 2017 - pubs.rsc.org
A significant number of synthetic systems capable of replicating themselves or entities that
are complementary to themselves have appeared in the last 30 years. Building on an …

Uncovering the selection criteria for the emergence of multi-building-block replicators from dynamic combinatorial libraries

M Malakoutikhah, JJP Peyralans… - Journal of the …, 2013 - ACS Publications
A family of self-replicating macrocycles was developed using dynamic combinatorial
chemistry. Replication is driven by self-assembly of the replicators into fibrils and relies …

Welcome home, systems chemists!

G von Kiedrowski, S Otto, P Herdewijn - Journal of Systems Chemistry, 2010 - Springer
It is our utmost pleasure to launch the Journal of Systems Chemistry. What systems
chemistry exactly is will be known in a few years from now when one is able to sketch the …

Transient fibril structures facilitating nonenzymatic self-replication

B Rubinov, N Wagner, M Matmor, O Regev… - ACS …, 2012 - ACS Publications
An emerging new direction of research focuses on developing “self-synthesizing materials”,
those supramolecular structures that can promote their own formation by accelerating the …

A dynamic covalent, luminescent metallopolymer that undergoes sol-to-gel transition on temperature rise

X de Hatten, N Bell, N Yufa, G Christmann… - Journal of the …, 2011 - ACS Publications
The condensation of linear diamine and dialdehyde subcomponents around copper (I)
templates in the presence of bulky trioctylphosphine ancillary ligands gave a linear …

Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks

AK Bandela, N Wagner, H Sadihov… - Proceedings of the …, 2021 - National Acad Sciences
Many fundamental cellular and viral functions, including replication and translation, involve
complex ensembles hosting synergistic activity between nucleic acids and …

Artificial Homeostasis Systems Based on Feedback Reaction Networks: Design Principles and Future Promises

VA Ranganath, I Maity - Angewandte Chemie International …, 2024 - Wiley Online Library
Feedback‐controlled chemical reaction networks (FCRNs) are indispensable for various
biological processes, such as cellular mechanisms, patterns, and signaling pathways …