Invasive fungal infections represent a significant global health problem, and present several
clinical challenges, including limited treatment options, increasing rates of antifungal drug …

Rationale: Pulmonary aspergillosis is a lethal mold infection in the immunocompromised
host. Understanding initial control of infection and how this is altered in the …

The immune mechanisms that recognize inhaled Aspergillus fumigatus conidia to promote
their elimination from the lungs are incompletely understood. FleA is a lectin expressed by …

Environmental fungi are globally ubiquitous and human exposure is near universal.
However, relatively few fungal species are capable of infecting humans, and among fungi …

Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related
mortality and can occur with any type of transfusion. TRALI is thought to be primarily …

A. fumigatus appears to have an important role in CF lung disease, not exclusive to the
context of ABPA. However, a causal relationship still needs to be confirmed. Study …

The concept that macrophages play an active role in inflammatory responses began its
development in the late 1800s with the now iconic studies by Elie Metchnikoff using starfish …

Fungal diseases represent an important paradigm in immunology since they can result from
either the lack of recognition or over-activation of the inflammatory response. Current …

Abstract RIG-I–like receptors (RLR) are cytosolic RNA sensors that signal through the MAVS
adaptor to activate IFN responses against viruses. Whether the RLR family has broader …

Humans are constantly exposed to fungi, either in the form of commensals at epithelial
barriers or as inhaled spores. Innate immune cells play a pivotal role in maintaining …