Although non-eosinophilic asthma (NEA) is not the best known and most prevalent asthma
phenotype, its importance cannot be underestimated. NEA is characterized by airway …

Severe asthma accounts for only a small proportion of the children with asthma but a
disproportionately high amount of resource utilization and morbidity. It is a heterogeneous …

Asthma is one of the most common chronic diseases in children, with a high proportion of
patients demonstrating poor control despite the availability of disease management …

Introduction: Asthma is a chronic disease with significant heterogeneity in clinical features,
disease severity, pattern of underlying disease mechanisms, and responsiveness to specific …

The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) affects almost everyone in the world in many ways …

Tiotropium bromide is the only long-acting muscarinic antagonist (LAMA) approved for
treatment of patients aged≥ 6 years old who have symptoms of uncontrolled asthma …

The airway epithelium stretches and relaxes during the normal respiratory cycle, and
hyperventilation exaggerates this effect, resulting in changes in lung physiology. In fact …

Abstract Background The Global Initiative for Asthma has only recently added tiotropium
bromide as adjunct controller therapy in severe asthma (Step 4 or 5) in adults (2015) and …

In the upcoming years, the proportion of elderly patients with chronic obstructive pulmonary
disease (COPD) will increase, according to the progressively aging population and the …

Introduction The role of long-acting muscarinic antagonists (LAMAs) is well established in
uncontrolled asthma, but not in milder stages. Areas covered This review examines the main …