Dysregulated lipid metabolism is implicated in the pathophysiology of a range of kidney
diseases. The specific mechanisms through which lipotoxicity contributes to acute kidney …

Cardiovascular diseases (CVDs), a group of disorders affecting the heart or blood vessels,
are the primary cause of death worldwide, with an immense impact on patient quality of life …

Mutations in mitochondrial DNA as well as nuclear-encoded mitochondrial proteins have
been reported to cause tubulointerstitial kidney diseases and focal segmental …

Abstract Background Dexmedetomidine (Dex) is a safe and effective anesthetic adjunct
which also has neuroprotective roles. This study aimed to validate the role of Dex in hypoxic …

Mitochondria regulate steroid hormone synthesis, and in turn sex hormones regulate
mitochondrial function for maintaining cellular homeostasis and controlling inflammation …

Hyperoxia is frequently used for treating acute respiratory failure, but it can cause acute lung
injury. Nucleotide-binding domain and leucine-rich-repeat-containing family member X1 …

The activation of microglia and the production of cytokines are key factors contributing to
progressive neurodegeneration. Despite the well-recognized neuronal programmed cell …

Anti-partial epithelial-mesenchymal transition (pEMT) treatment of renal tubular epithelial
cells (TECs) represents a promising therapeutic approach. Hyperuricemia nephropathy (HN) …

Mitophagy is an important mechanism for mitochondrial quality control by regulating
autophagosome-specific phagocytosis, degradation and clearance of damaged …

Increasing evidence indicates the major role of mitochondrial function in neurodegenerative
disease. However, it is unclear whether mitochondrial dynamics directly affect postoperative …