Underlying mechanisms and related diseases behind the complex regulatory role of NOD-like receptor X1

H Shi, ZM Zhou, L Zhu, L Chen, ZL Jiang… - DNA and Cell …, 2022 - liebertpub.com
Among nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), NOD-like
receptor X1 (NLRX1) is the only known NLR family member that is targeted to the …

[HTML][HTML] Improvement of E Se tea extracts on renal mesangial cell apoptosis and high-fat-diet/streptozotocin-induced diabetic nephropathy

M Tan, C Fan, M Wang, X Li, R Yuan, J Yang… - Journal of Functional …, 2021 - Elsevier
E Se tea, the leaves of Malus toringoides (Rehd.) Hughes, is a kind of traditional beverage,
which is often used to relieve hyperglycemia and hyperlipidemia and other symptoms, while …

Cellular Context Dictates the Suppression or Augmentation of Triple-Negative Mammary Tumor Metastasis by NLRX1

MA Nagai-Singer, MK Woolls, K Leedy… - The Journal of …, 2023 - journals.aai.org
Prior studies have defined multiple, but inconsistent, roles for the enigmatic pattern
recognition receptor NLRX1 in regulating several cancer-associated biological functions. In …

[PDF][PDF] Nitroxide-enhanced magnetic resonance imaging of kidney dysfunction in vivo based on redox-imbalance and oxidative stress

D Lazarova, S Shibata, I Ishii, G Zlateva… - Gen Physiol …, 2019 - academia.edu
This study reports a non-invasive magnetic resonance imaging (MRI) of kidney dysfunction
in mice, based on the induction of redox-imbalance and oxidative stress in the renal tissues …

Protective mechanisms of quercetin in neonatal rat brain injury induced by hypoxic‐ischemic brain damage (HIBD)

Y Xu, J Xu, L Chen, W Su, Q Zhu… - Food Science & …, 2023 - Wiley Online Library
Neonatal hypoxic‐ischemic brain damage (HIBD) is a leading cause of infant mortality
worldwide. This study explored whether quercetin (Que) exerts neuroprotective effects in a …

NLRX1: a key regulator in mitochondrial respiration and colorectal cancer progression

Y Ding, W Sun, M Han, Z Liu, H Kang, X Ma, J Wang… - Medical Oncology, 2024 - Springer
Colorectal cancer (CRC) is a prevalent and aggressive malignancy with high mortality rates
and significant risks to human well-being. Population-wide screening for tumor suppressor …

[HTML][HTML] Sestrin2 protects against hypoxic nerve injury by regulating mitophagy through SESN2/AMPK pathway

C Pan, C Ai, L Liang, B Zhang, Q Li, L Pu… - Frontiers in Molecular …, 2023 - ncbi.nlm.nih.gov
Hypoxia induced by high altitude can lead to severe neurological dysfunction. Mitophagy is
known to play a crucial role in hypoxic nerve injury. However, the regulatory mechanism of …

NLRX1 does not play a role in diabetes nor the development of diabetic nephropathy induced by multiple low doses of streptozotocin

AML Scantlebery, M Uil, LM Butter, R Poelman… - PloS one, 2019 - journals.plos.org
Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus that results
in both tubular and glomerular injury. Low-grade inflammation and oxidative stress are two …

Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific

B Kastelberg, T Ayubi, N Tubau-Juni, A Leber… - Frontiers in …, 2021 - frontiersin.org
The Nlr family member X1 (Nlrx1) is an immuno-metabolic hub involved in mediating
effective responses to virus, bacteria, fungi, cancer, and auto-immune diseases. We have …

LncRNA SNHG12 ameliorates bupivacaine-induced neurotoxicity by sponging miR-497–5p to upregulate NLRX1

L Sun, R Yuan - Human & Experimental Toxicology, 2022 - journals.sagepub.com
Long non-coding RNA (lncRNA) small nucleolar RNA host gene 12 (SNHG12) has been
reported to participate in the regulation of various nervous system disorders. Bupivacaine …