Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

INTRODUCTION Lysosomes are degradative organelles that break down diverse materials
delivered from inside and outside the cell by specialized vesicles called endosomes …

Sensing and clearance of dysfunctional lysosomes is critical for cellular homeostasis. Here
we show that transcription factor EB (TFEB)—a master transcriptional regulator of lysosomal …

Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …

Droplet manipulations are fundamental to numerous applications, such as water collection,
medical diagnostics, and drug delivery. Structure-based liquid operations have been widely …

Inflammation, a process intimately linked to renal disease, can be defined as a complex
network of interactions between renal parenchymal cells and resident immune cells, such as …

Apoptotic cell death is usually a response to the cell's microenvironment. In the kidney,
apoptosis contributes to parenchymal cell loss in the course of acute and chronic renal …

Hyperoxaluria results from either inherited disorders of glyoxylate metabolism leading to
hepatic oxalate overproduction (primary hyperoxaluria), or increased intestinal oxalate …

The physiological process of biomineralization is complex and deviation from it leads to a
variety of diseases. Progress in the past 10 years has enhanced understanding of the …