Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer

A Soleimani, F Rahmani, GA Ferns, M Ryzhikov… - Gene, 2020 - Elsevier
The NF-κB signaling pathway is a key regulator of CRC cell proliferation, apoptosis,
angiogenesis, inflammation, metastasis, and drug resistance. Over-activation of the NF-κB …

Advantages and drawbacks of dexamethasone in glioblastoma multiforme

AR Afshari, M Sanati, S Aminyavari, F Shakeri… - Critical Reviews in …, 2022 - Elsevier
The most widespread, malignant, and deadliest type of glial tumor is glioblastoma
multiforme (GBM). Despite radiation, chemotherapy, and radical surgery, the median …

G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment

Y Lee, NF Lahens, S Zhang, J Bedont, JM Field… - PLoS …, 2019 - journals.plos.org
Circadian disruption has multiple pathological consequences, but the underlying
mechanisms are largely unknown. To address such mechanisms, we subjected transformed …

Dexamethasone loaded liposomes by thin-film hydration and microfluidic procedures: formulation challenges

MD Al-Amin, F Bellato, F Mastrotto, M Garofalo… - International journal of …, 2020 - mdpi.com
Liposomes have been one of the most exploited drug delivery systems in recent decades.
However, their large-scale production with low batch-to-batch differences is a challenge for …

Harnessing hyaluronic acid-based nanoparticles for combination therapy: A novel approach for suppressing systemic inflammation and to promote antitumor …

VK Rangasami, S Samanta, VS Parihar, K Asawa… - Carbohydrate …, 2021 - Elsevier
Anti-inflammatory drugs such as dexamethasone (DEX) are commonly administered to
cancer patients along with anticancer drugs, however, the effect of DEX on human cancers …

Dexamethasone inhibits pancreatic tumor growth in preclinical models: Involvement of activating glucocorticoid receptor

Y Yao, Q Yao, J Xue, X Tian, Q An, L Cui, C Xu… - Toxicology and Applied …, 2020 - Elsevier
Glucocorticoid receptor (GR) modulates extensive biological and pathological processes
including tumor progression through diverse mechanisms. The regulatory effects of …

Reactive oxygen species as mediators of disease progression and therapeutic response in colorectal cancer

NJ Lyons, R Giri, J Begun, D Clark, D Proud… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Reactive oxygen species (ROS) are critical to normal cellular function with
redox homeostasis achieved by balancing ROS production with removal through …

Use of zebrafish larvae lateral line to study protection against cisplatin-induced ototoxicity: A scoping review

E Domarecka, M Skarzynska… - International journal …, 2020 - journals.sagepub.com
Aim: The present review aimed to consolidate and analyze the recent information about the
use of zebrafish in studies concerning cisplatin-induced ototoxicity and otoprotection …

Caged Dexamethasone/Quercetin Nanoparticles, Formed of the Morphogenetic Active Inorganic Polyphosphate, are Strong Inducers of MUC5AC

M Neufurth, X Wang, S Wang, HC Schröder… - Marine Drugs, 2021 - mdpi.com
Inorganic polyphosphate (polyP) is a widely distributed polymer found from bacteria to
animals, including marine species. This polymer exhibits morphogenetic as well as antiviral …

Novel primary human cancer stem-like cell populations from non-small cell lung cancer: inhibition of cell survival by targeting NF-κB and MYC signaling

BA Windmoeller, M Beshay, LP Helweg, C Flottmann… - Cells, 2021 - mdpi.com
There is growing evidence that cancer stem cells (CSCs), a small subpopulation of self-
renewal cancer cells, are responsible for tumor growth, treatment resistance, and cancer …