The good, the bad and the new about uric acid in cancer

S Allegrini, M Garcia-Gil, R Pesi, M Camici, MG Tozzi - Cancers, 2022 - mdpi.com
Simple Summary The concentration of uric acid in blood is sex-, age-and diet-dependent
and is maintained close to its maximal solubility, indicating that it plays some important role …

PAICS as a potential target for cancer therapy linking purine biosynthesis to cancer progression

A Huo, X Xiong - Life Sciences, 2023 - Elsevier
Tumor cells are required to undergo metabolic reprogramming for rapid development and
progression, and one of the metabolic characteristics of cancer cells is the excessive …

Impairment of kidney function and kidney cancer: A bidirectional Mendelian randomization study

Y Lin, Y Yang, T Fu, L Lin, X Zhang, Q Guo… - Cancer …, 2023 - Wiley Online Library
Background Many observational epidemiology studies discovered that kidney cancer and
impaired kidney function have a bidirectional relationship. However, it remains unclear …

Organic anion transporters (OAT) and other SLC22 transporters in progression of renal cell carcinoma

TC Whisenant, SK Nigam - Cancers, 2022 - mdpi.com
Simple Summary Kidney cancer diagnoses make up over 2% of newly identified cancers
each year. SoLute Carrier 22 (SLC22) genes are expressed in normal functioning kidneys …

High-Accuracy Renal Cell Carcinoma Discrimination through Label-Free SERS of Blood Serum and Multivariate Analysis

BA Buhas, V Toma, N Crisan, G Ploussard, TA Maghiar… - Biosensors, 2023 - mdpi.com
Renal cell carcinoma (RCC) represents the sixth most frequently diagnosed cancer in men
and is asymptomatic, being detected mostly incidentally. The apparition of symptoms …

Comprehensive Analysis of Purine-Metabolism-Related Gene Signature for Predicting Ovarian Cancer Prognosis, Immune Landscape, and Potential Treatment …

J Liu, X Zhang, H Wang, X Zuo, L Hong - Journal of Personalized …, 2023 - mdpi.com
Purine metabolism is an important branch of metabolic reprogramming and has received
increasing attention in cancer research. Ovarian cancer is an extremely dangerous …

Analysis of the prognostic value of uric acid on the efficacy of immunotherapy in patients with primary liver cancer

H Rao, Q Wang, X Zeng, X Wen, L Huang - Clinical and Translational …, 2024 - Springer
Purpose Uric acid (UA) plays a dual role as an antioxidant and a prooxidant in patients with
malignant tumors; however, the relationship between serum UA and malignancy is currently …

SERS liquid biopsy profiling of serum for the diagnosis of kidney cancer

T Moisoiu, SD Iancu, D Burghelea, MP Dragomir… - Biomedicines, 2022 - mdpi.com
Renal cancer (RC) represents 3% of all cancers, with a 2% annual increase in incidence
worldwide, opening the discussion about the need for screening. However, no established …

Can uric acid affect the immune microenvironment in bladder cancer? A single‐center multi‐omics study

H Chen, D Shi, C Guo, W Zhang, Y Guo… - Molecular …, 2024 - Wiley Online Library
Metabolic abnormalities are one of the important factors in bladder cancer (BCa)
progression and microenvironmental disturbance. As an important product of purine …

[HTML][HTML] Elevated serum uric acid is associated with the risk of advanced staging and vascular involvement in patients with hepatoblastoma: a 14-year retrospective …

Y Zhou, J Li, Y Ma, M Tang, X Yuan, L Shen - Frontiers in Oncology, 2023 - frontiersin.org
Background: Uric acid is the end product of the purine metabolism pathway, and has been
linked to cancer risks and prognosis, but its relationship with hepatoblastoma (HB) remains …