Targeted inhibitors of EGFR: structure, biology, biomarkers, and clinical applications
N Shaban, D Kamashev, A Emelianova, A Buzdin - Cells, 2023 - mdpi.com
Members of the EGFR family of tyrosine kinase receptors are major regulators of cellular
proliferation, differentiation, and survival. In humans, abnormal activation of EGFR is …
proliferation, differentiation, and survival. In humans, abnormal activation of EGFR is …
Evaluating the utility of therapeutic drug monitoring in the clinical use of small molecule kinase inhibitors: a review of the literature
A Fahmy, AM Hopkins, MJ Sorich… - Expert Opinion on Drug …, 2021 - Taylor & Francis
Introduction: Orally administered small molecule kinase inhibitors (KI) are a key class of
targeted anti-cancer medicines that have contributed substantially to improved survival …
targeted anti-cancer medicines that have contributed substantially to improved survival …
Spindle cell lesions with oncogenic EGFR kinase domain aberrations: expanding the spectrum of protein kinase-related mesenchymal tumors
S Vallese, S Barresi, L Hiemcke-Jiwa, S Patrizi… - Modern Pathology, 2024 - Elsevier
ABSTRACT EGFR aberrations are reported in a subset of myofibroblastic lesions with
kinase domain duplication (EGFR-KDD) and exon 20 mutations being assigned to infantile …
kinase domain duplication (EGFR-KDD) and exon 20 mutations being assigned to infantile …