Microglia states and nomenclature: A field at its crossroads

RC Paolicelli, A Sierra, B Stevens, ME Tremblay… - Neuron, 2022 - cell.com
Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …

Microglia and central nervous system–associated macrophages—from origin to disease modulation

M Prinz, T Masuda, MA Wheeler… - Annual review of …, 2021 - annualreviews.org
The immune system of the central nervous system (CNS) consists primarily of innate
immune cells. These are highly specialized macrophages found either in the parenchyma …

Directed evolution of adeno-associated virus for efficient gene delivery to microglia

R Lin, Y Zhou, T Yan, R Wang, H Li, Z Wu, X Zhang… - Nature …, 2022 - nature.com
As the resident immune cells in the central nervous system (CNS), microglia orchestrate
immune responses and dynamically sculpt neural circuits in the CNS. Microglial dysfunction …

Strategies to mitigate the impact of COVID-19 on supply chain disruptions: a multiple case analysis of buyers and distributors

AS Butt - The International Journal of Logistics Management, 2021 - emerald.com
Purpose This paper explores the steps/countermeasures taken by buying and distributing
firms to address supply chain disruptions caused by COVID-19. Design/methodology …

[HTML][HTML] Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function

AG Spiteri, CL Wishart, R Pamphlett, G Locatelli… - Acta …, 2022 - Springer
In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

[HTML][HTML] ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain

V Stratoulias, R Ruiz, S Kanatani, AM Osman… - Nature …, 2023 - nature.com
Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether
microglial subsets characterized by the expression of specific proteins constitute subtypes …

[HTML][HTML] Influence of digital accounting system usage on SMEs performance: The moderating effect of COVID-19

A Lutfi, SN Alkelani, MA Al-Khasawneh, AF Alshira'h… - Sustainability, 2022 - mdpi.com
In the literature, studies have evidenced the efforts adopted by firms to develop digital
technology with the hope of achieving sustainable decisions and competitive performance …

[PDF][PDF] A binary Cre transgenic approach dissects microglia and CNS border-associated macrophages

JS Kim, M Kolesnikov, S Peled-Hajaj, I Scheyltjens… - Immunity, 2021 - cell.com
The developmental and molecular heterogeneity of tissue macrophages is unravelling, as
are their diverse contributions to physiology and pathophysiology. Moreover, also given …

Microglial/Macrophage polarization and function in brain injury and repair after stroke

J Lyu, D Xie, TN Bhatia, RK Leak… - CNS neuroscience & …, 2021 - Wiley Online Library
Stroke is a leading cause of disability and mortality, with limited treatment options. After
stroke injury, microglia and CNS‐resident macrophages are rapidly activated and regulate …

Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion

FA Pinho-Ribeiro, L Deng, DV Neel, O Erdogan… - Nature, 2023 - nature.com
The meninges are densely innervated by nociceptive sensory neurons that mediate pain
and headache,. Bacterial meningitis causes life-threatening infections of the meninges and …