Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit
bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a …

Alzheimer's disease (AD) is a progressive, neurodegenerative disease and the most
common form of dementia in elderly people. It is an emerging public health problem that …

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by
previous studies; however, a large portion of the genetic risk for this disease remains …

The kindlin (or fermitin) family of proteins comprises three members (kindlin-1,-2 and-3) of
evolutionarily conserved focal adhesion (FA) proteins, whose best-known task is to increase …

From the initial description of platelets in 1882, their propensity to aggregate and to
contribute to thrombosis was apparent. Indeed, excessive platelet aggregation is associated …

The endothelium is a dynamic, semipermeable layer lining all blood vessels, regulating
blood vessel formation and barrier function. Proper composition and function of the …

Focal adhesions are protein complexes that link metazoan cells to the extracellular matrix
through the integrin family of transmembrane proteins. Integrins recruit many proteins to …

Reduced levels of kindlin-2 (K2) in endothelial cells derived from K2+/− mice or C2C12
myoblastoid cells treated with K2 siRNA showed disorganization of their actin cytoskeleton …

Interplay between tumor cells and host cells in the tumor microenvironment dictates the
development of all cancers. In breast cancer, malignant cells educate host macrophages to …

Increasing evidence has suggested a critical role for endothelial‐to‐mesenchymal transition
(EndoMT) in a variety of pathological conditions. MicroRNA‐200c‐3p (miR‐200c‐3p) has …