[HTML][HTML] The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation
DNA methylation plays an important role in mammalian development and correlates with
chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG …
chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG …
[HTML][HTML] The molecular basis of MeCP2 function in the brain
R Tillotson, A Bird - Journal of molecular biology, 2020 - Elsevier
MeCP2 is a reader of the DNA methylome that occupies a large proportion of the genome
due to its high abundance and the frequency of its target sites. It has been the subject of …
due to its high abundance and the frequency of its target sites. It has been the subject of …
MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome
Epigenetic mechanisms, such as DNA methylation, regulate transcriptional programs to
afford the genome flexibility in responding to developmental and environmental cues in …
afford the genome flexibility in responding to developmental and environmental cues in …
[HTML][HTML] Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons
Rett syndrome (RTT) is caused by mutations of MECP2, a methyl CpG binding protein
thought to act as a global transcriptional repressor. Here we show, using an isogenic human …
thought to act as a global transcriptional repressor. Here we show, using an isogenic human …
[HTML][HTML] Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation
Z Zhou, EJ Hong, S Cohen, W Zhao, HH Ho, L Schmidt… - Neuron, 2006 - cell.com
Mutations or duplications in MECP2 cause Rett and Rett-like syndromes,
neurodevelopmental disorders characterized by mental retardation, motor dysfunction, and …
neurodevelopmental disorders characterized by mental retardation, motor dysfunction, and …
Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice
Rett Syndrome (RTT) is a severe form of X-linked mental retardation caused by mutations in
the gene coding for methyl CpG-binding protein 2 (MECP2). Mice deficient in MeCP2 have a …
the gene coding for methyl CpG-binding protein 2 (MECP2). Mice deficient in MeCP2 have a …
[HTML][HTML] Modeling Rett syndrome using TALEN-edited MECP2 mutant cynomolgus monkeys
Gene-editing technologies have made it feasible to create nonhuman primate models for
human genetic disorders. Here, we report detailed genotypes and phenotypes of TALEN …
human genetic disorders. Here, we report detailed genotypes and phenotypes of TALEN …
Interactions of innate and adaptive immunity in brain development and function
It has been known for decades that the immune system has a tremendous impact on
behavior. Most work has described the negative role of immune cells on the central nervous …
behavior. Most work has described the negative role of immune cells on the central nervous …
Histone H2A. Z and DNA methylation are mutually antagonistic chromatin marks
Eukaryotic chromatin is separated into functional domains differentiated by post-translational
histone modifications, histone variants and DNA methylation,,,,,. Methylation is associated …
histone modifications, histone variants and DNA methylation,,,,,. Methylation is associated …
The role of MeCP2 in the brain
J Guy, H Cheval, J Selfridge… - Annual review of cell and …, 2011 - annualreviews.org
Methyl-CpG binding protein 2 (MeCP2) was first identified in 1992 as a protein that binds
specifically to methylated DNA. Mutations in the MECP2 gene were later found to be the …
specifically to methylated DNA. Mutations in the MECP2 gene were later found to be the …