In the 50 years since Andreas Rett first described the syndrome that came to bear his name,
and is now known to be caused by a mutation in the methyl-CpG-binding protein 2 (MECP2) …

DNA methylation is a major epigenetic modification in the genomes of higher eukaryotes. In
vertebrates, DNA methylation occurs predominantly on the CpG dinucleotide, and …

In mammals, the environment plays a critical role in promoting the final steps in neuronal
development during the early postnatal period. While epigenetic factors are thought to …

Mutations in the methyl-CpG binding protein 2 (MECP2) gene cause Rett syndrome (RTT), a
neurodevelopmental disorder characterized by the loss of language and motor skills during …

We often think of neurodevelopmental disorders as beginning before birth, and many
certainly do. A handful, however, strike many months after birth, following a period of …

Over the past decade, it has become increasingly obvious that epigenetic mechanisms are
an integral part of a multitude of brain functions that range from the development of the …

DNA methylation plays a critical role in the regulation of chromatin structure and gene
expression and is involved in a variety of biological processes. The levels and patterns of …

Rett Syndrome (RTT) is a devastating neurological disorder that is caused by mutations in
the MECP2 gene. Mecp2-mutant mice have been used as a model system to study the …

One of the most powerful tools that the molecular biology revolution has given us is the
ability to turn genes on and off at our discretion. In the mouse, this has been accomplished …

Mutations in the X-linked methyl-CpG-binding protein 2 (MECP2), encoding a transcriptional
repressor, cause Rett syndrome and a variety of related neurodevelopmental disorders. The …