Forever young: the first seventy years of ferrocene

P Štěpnička - Dalton Transactions, 2022 - pubs.rsc.org
The discovery of ferrocene,[Fe (η5-C5H5) 2], seventy years ago has significantly influenced
chemical research and provided a key impetus for establishing and rapidly expanding …

Has ferrocene really delivered its role in accentuating the bioactivity of organic scaffolds?

B Sharma, V Kumar - Journal of medicinal chemistry, 2021 - ACS Publications
Ferrocene is an important structural core in bioorganometallic chemistry because of its
inherent stability, excellent redox properties, and low toxicity. Ferroquine and ferrocifen are …

Ferroptosis‐enhanced cancer immunity by a ferrocene‐appended iridium (III) Diphosphine complex

WJ Wang, YY Ling, YM Zhong, ZY Li… - Angewandte Chemie …, 2022 - Wiley Online Library
Ferroptosis is a programmed cell death pathway discovered in recent years, and ferroptosis‐
inducing agents have great potential as new antitumor candidates. Here, we report a IrIII …

Ferrocene-containing hybrids as potential anticancer agents: Current developments, mechanisms of action and structure-activity relationships

R Wang, H Chen, W Yan, M Zheng, T Zhang… - European Journal of …, 2020 - Elsevier
Cancer is one of the most fatal threatens to human health throughout the world. The major
challenges in the control and eradication of cancers are the continuous emergency of drug …

[HTML][HTML] Ferrocene-based drugs, delivery nanomaterials and fenton mechanism: state of the art, recent developments and prospects

C Ornelas, D Astruc - Pharmaceutics, 2023 - mdpi.com
Ferrocene has been the most used organometallic moiety introduced in organic and
bioinorganic drugs to cure cancers and various other diseases. Following several …

[HTML][HTML] Expanding medicinal chemistry into 3D space: Metallofragments as 3D scaffolds for fragment-based drug discovery

CN Morrison, KE Prosser, RW Stokes, A Cordes… - Chemical …, 2020 - pubs.rsc.org
Fragment-based drug discovery (FBDD) is a powerful strategy for the identification of new
bioactive molecules. FBDD relies on fragment libraries, generally of modest size, but of high …

Self‐Amplifying Iridium (III) Photosensitizer for Ferroptosis‐Mediated Immunotherapy Against Transferrin Receptor‐Overexpressing Cancer

YY Ling, WJ Wang, L Hao, XW Wu, JH Liang, H Zhang… - Small, 2022 - Wiley Online Library
Photoimmunotherapy is attractive for cancer treatment due to its spatial controllability and
sustained responses. This work presents a ferrocene‐containing Ir (III) photosensitizer …

[HTML][HTML] Ferrocene-based compounds with antimalaria/anticancer activity

S Peter, BA Aderibigbe - Molecules, 2019 - mdpi.com
Malaria and cancer are chronic diseases. The challenge with drugs available for the
treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent …

[HTML][HTML] Contemporary developments in ferrocene chemistry: physical, chemical, biological and industrial aspects

U Rauf, G Shabir, S Bukhari, F Albericio, A Saeed - Molecules, 2023 - mdpi.com
Ferrocenyl-based compounds have many applications in diverse scientific disciplines,
including in polymer chemistry as redox dynamic polymers and dendrimers, in materials …

Enhancing the activity of drugs by conjugation to organometallic fragments

P Chellan, PJ Sadler - Chemistry–A European Journal, 2020 - Wiley Online Library
Resistance to chemotherapy is a current clinical problem, especially in the treatment of
microbial infections and cancer. One strategy to overcome this is to make new derivatives of …