Andrographolide is a labdane diterpene and the main active ingredient isolated from the
herb Andrographis paniculata. Andrographolide possesses diverse biological effects …

5′ AMP-activated protein kinase (AMPK) is known as metabolic sensor in mammalian cells
that becomes activated by an increasing adenosine monophosphate (AMP)/adenosine …

No approved therapies are available for nonalcoholic steatohepatitis (NASH). Adenosine
monophosphate–activated protein kinase (AMPK) is a central regulator of cell metabolism; …

Aim Metformin and empagliflozin combined therapy may have complementary effects that go
beyond the well-recognized targets of their monotherapy through AMPK activation …

Nonalcoholic steatohepatitis (NASH) is triggered by hepatocyte death through activation of
caspase 6, as a result of decreased adenosine monophosphate (AMP)-activated protein …

Although traditionally considered a glucose metabolism-associated modification, the O-
linked β-N-Acetylglucosamine (O-GlcNAc) regulatory system interacts extensively with lipids …

Protein kinases (PKs), one of the largest protein families, can be further divided into different
groups based on their substrate or structure and function. PKs are important signaling …

Obesity is a global epidemic and overwhelming evidence indicates that it is a risk factor for
numerous cancers, including hepatocellular carcinoma (HCC), the third leading cause of …

Nonalcoholic fatty liver disease (NAFLD) can be ameliorated by calorie restriction, which
leads to the suppressed somatotroph axis. Paradoxically, the suppressed somatotroph axis …

The molecular mechanisms by which dietary fruits and vegetables confer cardiometabolic
benefits remain poorly understood. Historically, these beneficial properties have been …