The CXC chemokine CXCL12 is an important factor in physiological and pathological
processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation …

Chemokines are chemo tactic cyto kines that control the migratory patterns and positioning
of all immune cells. Although chemokines were initially appreciated as important mediators …

The unique properties of mesenchymal stromal/stem cells (MSCs) to self-renew and their
multipotentiality have rendered them attractive to researchers and clinicians. In addition to …

Stem cell homing is a multistep endogenous physiologic process that is also used by
exogenously administered hematopoietic stem and progenitor cells (HSPCs). This multistep …

Although haematopoietic stem cells (HSCs) are commonly assumed to reside within a
specialized microenvironment, or niche, most published experimental manipulations of the …

Acute-on-chronic liver failure (ACLF) is a distinct clinical entity and differs from acute liver
failure and decompensated cirrhosis in timing, presence of acute precipitant, course of …

Unique among leukocytes, neutrophils follow daily cycles of release from and migration
back into the bone marrow, where they are eliminated. Because removal of dying cells …

In adult mammals, hematopoietic stem cells (HSCs) are defined by their abilities to self‐
renew and to differentiate to form all blood cell lineages. These rare multipotent cells occupy …

Chronic inflammation fosters cancer development and progression and also modulates
tumor responses to anticancer therapies. Neutrophils are key effector cells in innate …

Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis
for their effector functions. How glycolysis and its major byproduct lactate are triggered in …