Metabolism and bioavailability of olive bioactive constituents based on in vitro, in vivo and human studies

T Nikou, ME Sakavitsi, E Kalampokis, M Halabalaki - Nutrients, 2022 - mdpi.com
Consumption of olive products has been established as a health-promoting dietary pattern
due to their high content in compounds with eminent pharmacological properties and well …

Translating kratom-drug interactions: from bedside to bench and back

RS Tanna, NB Cech, NH Oberlies, AE Rettie… - Drug Metabolism and …, 2023 - ASPET
Kratom is a botanical natural product belonging to the coffee family, with stimulant effects at
low doses and opioid-like effects at higher doses. During the last two decades, kratom has …

Developing a knowledge graph for pharmacokinetic natural product-drug interactions

SB Taneja, TJ Callahan, MF Paine, SL Kane-Gill… - Journal of biomedical …, 2023 - Elsevier
Background Pharmacokinetic natural product-drug interactions (NPDIs) occur when
botanical or other natural products are co-consumed with pharmaceutical drugs. With the …

Curcumae longae Rhizoma (Jianghuang) extract reverses the 5-Fluoruracil resistance in colorectal cancer cells via TLR4/PI3K/Akt/mTOR pathway

Z Teng, X Sun, Y Guo, M Zhang, Y Liu, M Xu - Clinics and Research in …, 2022 - Elsevier
Objectives Intensive efforts have been made in the area of identifying drug resistance
modulators from traditional Chinese medicine. Various natural plant extracts have been …

Plant‐derived virulence arresting drugs as novel antimicrobial agents: Discovery, perspective, and challenges in clinical use

L Lu, J Wang, C Wang, J Zhu, H Wang… - Phytotherapy …, 2024 - Wiley Online Library
Antimicrobial resistance (AMR) emerges as a severe crisis to public health and requires
global action. The occurrence of bacterial pathogens with multi‐drug resistance appeals to …

Discovery of Ring-Annulated Analogues of Cannabidiol as Potential Anticancer Agents: Synthesis and Biological Evaluation

PS Cham, A Singh, A Jamwal, R Singh… - ACS Medicinal …, 2024 - ACS Publications
Cannabidiol (CBD) is a nonpsychoactive cannabinoid derived from Cannabis sativa and its
potential therapeutic effects extend beyond its well-known antiepileptic properties. Exploring …

Enhanced absorption of prenylated cinnamic acid derivatives from Brazilian green propolis by turmeric in humans and rats

M Yamaga, H Kawabe, H Tani… - Food Science & …, 2024 - Wiley Online Library
Prenylated cinnamic acid derivatives are the bioactive components of Brazilian green
propolis (BGP). The effect of other botanical components on the pharmacokinetic profiles of …

Natural Products Inhibition of Cytochrome P450 2B6 Activity and Methadone Metabolism

PF Wang, Y Yang, V Patel, A Neiner… - Drug Metabolism and …, 2024 - ASPET
Methadone is cleared predominately by hepatic cytochrome P450 (CYP) 2B6-catalyzed
metabolism to inactive metabolites. CYP2B6 also catalyzes the metabolism of several other …

Natural products exert anti-tumor effects by regulating exosomal ncRNA

S Hu, Y Liu, S Guan, Z Qiu, D Liu - Frontiers in oncology, 2022 - frontiersin.org
Currently, more than 60% of the approved anti-cancer drugs come from or are related to
natural products. Natural products and exosomal non-coding RNAs (ncRNAs) exert anti …

[HTML][HTML] Incidence of Elevated Liver Enzyme Levels in Patients Receiving Remdesivir and Its Effective Factors

F Seyedalipour, S Alipour… - Middle East Journal …, 2024 - pmc.ncbi.nlm.nih.gov
Background: Emergency use of remdesivir was approved for COVID-19 in some countries.
Based on the promising results of remdesivir, the most common side effects were nausea …