It is estimated that nearly a third of people who abuse drugs started with prescription opioid
medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in …

Allostery is a universal, biological phenomenon in which orthosteric sites are fine‐tuned by
topologically distal allosteric sites triggered by perturbations, such as ligand binding, residue …

Recent advances in structural biology and computational techniques have revealed
allosteric mechanisms for an abundance of targets leading to the establishment of rational …

Directed evolution has emerged as a powerful strategy to engineer various properties of
proteins. Traditional methods to construct libraries such as error-prone PCR and DNA …

Here, we discuss the principles of allosteric activating mutations, propagation downstream of
the signals that they prompt, and allosteric drugs, with examples from the Ras signaling …

SARS-CoV-2 has caused the largest pandemic of the twenty-first century (COVID-19),
threatening the life and economy of all countries in the world. The identification of novel …

Metabolic reprogramming is observed across all cancer types. Indeed, the success of many
classic chemotherapies stems from their targeting of cancer metabolism. Contemporary …

Cancer immunotherapy with immune-checkpoint blockade has improved the outcomes of
patients with various malignancies, yet a majority do not benefit or develop resistance. To …

Progress in technology and algorithms throughout the past decade has transformed the field
of protein design and engineering. Computational approaches have become well-engrained …

The number of preclinical and clinical studies evaluating natural products-based
management of dementia has gradually increased, with an exponential rise in 2020 and …