Due to the lack of specific vaccines, management of the trypanosomatid-caused neglected
tropical diseases (sleeping sickness, Chagas disease and leishmaniasis) relies exclusively …

Chagas' disease is the most important trypanosomiasis in the Western Hemisphere,
affecting millions of people and capable of producing serious disturbances of the heart and …

A new 5-nitroimidazole compound, l-methyl-2-(4-methylthiophenoxymethyl)-5-
nitroimidazole: fexinidazole, HOE 239, was found to be highly active against experimental …

The search for more effective drugs for the treatment of leishmaniasis and trypanosomiasis
has increasingly involved the use of in vitro screens. These possess the immediate …

Groups of mice were inoculated with six Trypanosoma cruzi strains and then treated with 32
mg/kg body weight allopurinol for 10 consecutive days. Effects of the drug on mortality rates …

Eight novel analogues of Nifurtimox, 4-[(5-nitrofurfurylidene) amino]-3-methylthiomorpholine-
1, 1-dioxide, containing alfa–beta unsaturated amides, were synthesized and evaluated for …

Abstract Culture of Trypanosoma cruzi (Tulahuen strain) in the presence of ethidium
bromide (1–20 μg/ml) resulted in dyskinetoplasty and inhibition of growth, to an extent …

Abstract A novel 8-aminoquinoline compound, 8 {6-4′(3—hydroxybutyl) piperazin—1′—
ylhexylamino}—6—methoxyquinoline di (hydrogen maleate), moxipraquine, 349C59, was …

Abstract Treatment failures have been recorded in the chemotherapy of protozoal diseases
almost since such therapy began. Failures may have a number of causes, only one of which …

The nitrovinylfuran, SQ 18 506, has a broad spectrum of antimicrobial activity (G (Idcbusch
and Basch, 1974; McRipley et al., 1974), including marked chemotherapeutic action in …