Crosstalk of the structural and zinc buffering properties of mammalian metallothionein-2
A Drozd, D Wojewska, MD Peris-Díaz… - Metallomics, 2018 - academic.oup.com
Abstract Metallothioneins (MTs), small cysteine-rich proteins, present in four major isoforms,
are key proteins involved in zinc and copper homeostasis in mammals. To date, only one X …
are key proteins involved in zinc and copper homeostasis in mammals. To date, only one X …
[HTML][HTML] Zinc as a Drug for Wilson's disease, non-alcoholic liver disease and COVID-19-related liver injury
P Coni, G Pichiri, JI Lachowicz, A Ravarino, F Ledda… - Molecules, 2021 - mdpi.com
Zinc is the second most abundant trace element in the human body, and it plays a
fundamental role in human physiology, being an integral component of hundreds of …
fundamental role in human physiology, being an integral component of hundreds of …
Zn2+ influx activates ERK and Akt signaling pathways
KJ Anson, GA Corbet… - Proceedings of the …, 2021 - National Acad Sciences
Zinc (Zn2+) is an essential metal in biology, and its bioavailability is highly regulated. Many
cell types exhibit fluctuations in Zn2+ that appear to play an important role in cellular …
cell types exhibit fluctuations in Zn2+ that appear to play an important role in cellular …
Invariant BECN1 CXXC motifs bind Zn2+ and regulate structure and function of the BECN1 intrinsically disordered region
S Mukhopadhyay, S Subedi, JB Hopkins, A Ugrinov… - Autophagy, 2024 - Taylor & Francis
Autophagy is an essential catabolic cellular homeostasis process conserved in all
eukaryotes. BECN1/Beclin 1, a key autophagy protein involved in autophagosome …
eukaryotes. BECN1/Beclin 1, a key autophagy protein involved in autophagosome …
Synthesis, structural characterization, and density functional theory calculations of the two new Zn (II) complexes as antibacterial and anticancer agents with a neutral …
A Beheshti, M Bahrani‐Pour, M Kolahi… - Applied …, 2021 - Wiley Online Library
Two new mono‐and dinuclear zinc (II) complexes with a formula of [Zn (LN) OMeCl](1) and
[Zn2 (LN)(N3) 2Cl2](2)[where LN= 1, 1, 3, 3‐tetrakis (3, 5‐dimethyl‐1‐pyrazolyl) propane)] …
[Zn2 (LN)(N3) 2Cl2](2)[where LN= 1, 1, 3, 3‐tetrakis (3, 5‐dimethyl‐1‐pyrazolyl) propane)] …
Metal-and affinity-specific dual labeling of cysteine-rich proteins for identification of metal-binding sites
MD Peris-Díaz, R Guran, O Zitka, V Adam… - Analytical …, 2020 - ACS Publications
Here, using human metallothionein (MT2) as an example, we describe an improved strategy
based on differential alkylation coupled to MS, assisted by zinc probe monitoring, for …
based on differential alkylation coupled to MS, assisted by zinc probe monitoring, for …
InterMetalDB: a database and browser of intermolecular metal binding sites in macromolecules with structural information
JB Tran, A Krężel - Journal of Proteome Research, 2021 - ACS Publications
InterMetalDB is a free-of-charge database and browser of intermolecular metal binding sites
that are present on the interfaces of macromolecules forming larger assemblies based on …
that are present on the interfaces of macromolecules forming larger assemblies based on …
[HTML][HTML] The critical roles of zinc: beyond impact on myocardial signaling
SR Lee, SJ Noh, JR Pronto, YJ Jeong… - The Korean journal of …, 2015 - ncbi.nlm.nih.gov
Zinc has been considered as a vital constituent of proteins, including enzymes. Mobile
reactive zinc (Zn 2+) is the key form of zinc involved in signal transductions, which are …
reactive zinc (Zn 2+) is the key form of zinc involved in signal transductions, which are …
[HTML][HTML] Metal-coupled folding as the driving force for the extreme stability of Rad50 zinc hook dimer assembly
T Kochańczyk, M Nowakowski, D Wojewska… - Scientific Reports, 2016 - nature.com
The binding of metal ions at the interface of protein complexes presents a unique and poorly
understood mechanism of molecular assembly. A remarkable example is the Rad50 zinc …
understood mechanism of molecular assembly. A remarkable example is the Rad50 zinc …
Optic nerve regeneration: A long view
Y Yin, S De Lima, HY Gilbert… - Restorative …, 2019 - content.iospress.com
The optic nerve conveys information about the outside world from the retina to multiple
subcortical relay centers. Until recently, the optic nerve was widely believed to be incapable …
subcortical relay centers. Until recently, the optic nerve was widely believed to be incapable …