Kinetics and thermodynamics of zinc (II) and arsenic (III) binding to XPA and PARP-1 zinc finger peptides

J Huestis, X Zhou, L Chen, C Feng, LG Hudson… - Journal of inorganic …, 2016 - Elsevier
Inhibition of DNA repair is an established mechanism of arsenic co-carcinogenesis, and may
be perpetuated by the binding of As (III) to key zinc finger (zf) DNA repair proteins. Validated …

Electrophoretic Determination of Lactococcus lactis Modified by Zinc Ions

B Buszewski, A Król, P Pomastowski… - Chromatographia, 2019 - Springer
The developed capillary electrophoresis (CE) method was applied to evaluate the
aggregation activity of divalent metal ions (zinc) on bacterial cells. In our study, the influence …

Tafluprost promotes axon regeneration after optic nerve crush via Zn2+-mTOR pathway

S Wu, C Liu, J Tang, C Wu, Q Zhang, Z Liu, J Han… - …, 2024 - Elsevier
Abstract Purpose To investigate whether Tafluprost could promote optic nerve regeneration
in mice after optic nerve crush (ONC) and determine the underlying molecular mechanism …

Comparison of Three Low-Molecular-Weight Fluorescent Probes for Measuring Free Zinc Levels in Cultured Mammary Cells

C Hübner, C Keil, A Jürgensen, L Barthel, H Haase - Nutrients, 2023 - mdpi.com
Free zinc is a critical regulator in signal transduction and affects many cellular processes
relevant to cancer, including proliferation and cell death. Acting as a second messenger …

Structural insight of the full-length Ros protein: a prototype of the prokaryotic zinc-finger family

G D'Abrosca, A Paladino, I Baglivo, L Russo… - Scientific Reports, 2020 - nature.com
Ros/MucR is a widespread family of bacterial zinc-finger (ZF) containing proteins that
integrate multiple functions such as virulence, symbiosis and/or cell cycle transcription. NMR …

Zinc trafficking: 1,10-phenanthroline, glutathione, and other metal binding ligands form adducts with proteomic Zn2+

K Fatema, E Lund, DH Petering - Metallomics, 2023 - academic.oup.com
Hypotheses were tested that the proteome of pig kidney LLC-PK1 cells (i) contains Zn-
proteins that react with a diversity of native and pharmacologically active metal-binding …

Biguanide is a modifiable pharmacophore for recruitment of endogenous Zn2+ to inhibit cysteinyl cathepsins: review and implications

TD Lockwood - Biometals, 2019 - Springer
Excessive activities of cysteinyl cathepsins (CysCts) contribute to the progress of many
diseases; however, therapeutic inhibition has been problematic. Zn 2+ is a natural inhibitor …

Zinc binding proteome of a phytopathogen Xanthomonas translucens pv. undulosa

A Sharma, D Sharma… - Royal Society Open …, 2019 - royalsocietypublishing.org
Xanthomonas translucens pv. undulosa (Xtu) is a proteobacteria which causes bacterial leaf
streak (BLS) or bacterial chaff disease in wheat and barley. The constant competition for zinc …

[HTML][HTML] Nanoscale technologies in the fight against COVID-19: from innovative nanomaterials to computer-aided discovery of potential antiviral plant-derived drugs

N Iraci, C Corsaro, SV Giofrè, G Neri, AM Mezzasalma… - Biomolecules, 2022 - mdpi.com
The last few years have increasingly emphasized the need to develop new active antiviral
products obtained from artificial synthesis processes using nanomaterials, but also derived …

The large intracellular loop of hZIP4 is an intrinsically disordered zinc binding domain

EM Bafaro, S Antala, TV Nguyen, SP Dzul… - Metallomics, 2015 - academic.oup.com
The human (h) ZIP4 transporter is a plasma membrane protein which functions to increase
the cytosolic concentration of zinc. hZIP4 transports zinc into intestinal cells and therefore …