The Nef protein of primate lentiviruses is a unique protein that has evolved in several ways
to manipulate the biology of an infected cell to support viral replication, immune evasion …

The twenty-first century has begun with considerable success for new AIDS vaccines in
macaque models. A common feature of these vaccines is their ability to induce high …

To understand the success or failure of immune responses against pathogens or tumours
requires the direct measurement of specific lymphocytes. Recently, there has been an …

Since the discovery of AIDS in 1981, the global spread of HIV has reached pandemic
proportions, representing a global developmental and public health threat. The development …

Envelope glycoproteins (Env) of lentiviruses typically possess unusually long cytoplasmic
domains, often 150 amino acids or longer. It is becoming increasingly clear that these …

An efficacious HIV-1 vaccine is regarded as the best way to halt the ongoing HIV-1
epidemic. However, despite significant efforts to develop a safe and effective vaccine, the …

Among the devastating consequences of AIDS has been its epidemic spread in the
developing world. The disease has caused unprecedented suffering, debilitation, loss of life …

Gene vaccines are a new approach to immunization and immunotherapy in which, rather
than a live or inactivated organism (or a subunit thereof), one or more genes that encode …

Plasma viral RNA load is a key parameter in disease progression of lentiviral infections. To
measure simian immunodeficiency virus (SIV) RNA loads, we have established a …

The DNA vaccine has proven to be one of the most promising applications in the field of
gene therapy. Due to its unique ability to readily induce humoral as well as cellular immune …