Effects of in Vivo Cd8+ T Cell Depletion on Virus Replication in Rhesus Macaques Immunized with a Live, Attenuated Simian Immunodeficiency Virus Vaccine
KJ Metzner, X Jin, FV Lee, A Gettie, DE Bauer… - The Journal of …, 2000 - rupress.org
The role of CD8+ T lymphocytes in controlling replication of live, attenuated simian
immunodeficiency virus (SIV) was investigated as part of a vaccine study to examine the …
immunodeficiency virus (SIV) was investigated as part of a vaccine study to examine the …
Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell …
H Horton, TU Vogel, DK Carter, K Vielhuber… - Journal of …, 2002 - Am Soc Microbiol
Producing a prophylactic vaccine for human immunodeficiency virus (HIV) has proven to be
a challenge. Most biological isolates of HIV are difficult to neutralize, so that conventional …
a challenge. Most biological isolates of HIV are difficult to neutralize, so that conventional …
Prospects for vaccine protection against HIV-1 infection and AIDS
NL Letvin, DH Barouch… - Annual Review of …, 2002 - annualreviews.org
The rapid and devastating spread of the AIDS epidemic in the developing world as well as
the difficulties associated with delivering antiretroviral drugs in affected countries underscore …
the difficulties associated with delivering antiretroviral drugs in affected countries underscore …
Priming of Strong, Broad, and Long-Lived HIV Type 1 p55gag-Specific CD8+ Cytotoxic T Cells after Administration of a Virus-Like Particle Vaccine in Rhesus …
X Paliard, Y Liu, R Wagner, H Wolf… - AIDS research and …, 2000 - liebertpub.com
Despite advances in the clinical management of HIV infection, using combinations of
antiretroviral pharmaceuticals, a safe and efficacious vaccine is needed to limit the AIDS …
antiretroviral pharmaceuticals, a safe and efficacious vaccine is needed to limit the AIDS …
Reduction of simian-human immunodeficiency virus 89.6 P viremia in rhesus monkeys by recombinant modified vaccinia virus Ankara vaccination
DH Barouch, S Santra, MJ Kuroda, JE Schmitz… - Journal of …, 2001 - Am Soc Microbiol
Since cytotoxic T lymphocytes (CTLs) are critical for controlling human immunodeficiency
virus type 1 (HIV-1) replication in infected individuals, candidate HIV-1 vaccines should elicit …
virus type 1 (HIV-1) replication in infected individuals, candidate HIV-1 vaccines should elicit …
A single injection of recombinant measles virus vaccines expressing human immunodeficiency virus (HIV) type 1 clade B envelope glycoproteins induces neutralizing …
C Lorin, L Mollet, F Delebecque, C Combredet… - Journal of …, 2004 - Am Soc Microbiol
The anchored and secreted forms of the human immunodeficiency virus type 1 (HIV-1) 89.6
envelope glycoprotein, either complete or after deletion of the V3 loop, were expressed in a …
envelope glycoprotein, either complete or after deletion of the V3 loop, were expressed in a …
First-in-Human Evaluation of the Safety and Immunogenicity of a Recombinant Vesicular Stomatitis Virus Human Immunodeficiency Virus-1 gag Vaccine (HVTN 090)
JD Fuchs, I Frank, ML Elizaga, M Allen… - Open forum …, 2015 - academic.oup.com
Background. We report the first-in-human safety and immunogenicity evaluation of a highly
attenuated, replication-competent recombinant vesicular stomatitis virus (rVSV) human …
attenuated, replication-competent recombinant vesicular stomatitis virus (rVSV) human …
Live attenuated HIV vaccines: pitfalls and prospects
JB Whitney, RM Ruprecht - Current opinion in infectious diseases, 2004 - journals.lww.com
Neither safety nor efficacy of the current live attenuated primate immunodeficiency virus
vaccines has withstood the test of time. However, such viruses are invaluable tools to …
vaccines has withstood the test of time. However, such viruses are invaluable tools to …
Characterization of Three nef-Defective Human Immunodeficiency Virus Type 1 Strains Associated with Long-Term Nonprogression
Long-term survivors (LTS) of human immunodeficiency virus type 1 (HIV-1) infection provide
an opportunity to investigate both viral and host factors that influence the rate of disease …
an opportunity to investigate both viral and host factors that influence the rate of disease …
Dendritic cells transduced by multiply deleted HIV-1 vectors exhibit normal phenotypes and functions and elicit an HIV-specific cytotoxic T-lymphocyte response in …
A Gruber, J Kan-Mitchell, KL Kuhen… - Blood, The Journal …, 2000 - ashpublications.org
Dendritic cells (DCs) genetically modified to continually express and present antigens may
be potent physiologic adjuvants for induction of prophylactic or therapeutic immunity. We …
be potent physiologic adjuvants for induction of prophylactic or therapeutic immunity. We …