ABSTRACT DNA vaccines, also referred to as genetic vaccines, are generating significant
preclinical and clinical interest. It has been proven that the expression of an antigen or …

Microparticles with entrapped antigens have recently been shown to possess significant
potential as vaccine delivery systems and adjuvants. However, the potential of …

HIV causes a chronic infection by evading immune eradication. A key element of HIV
immune escape is the HIV-1 Nef protein. Nef causes a reduction in the level of cell surface …

The human immunodeficiency virus type 1 (HIV-1) Nef protein is an important determinant of
AIDS pathogenesis. We have previously reported that HIV-1 Nef is responsible for the …

Recombinant, replication-competent rabies virus (RV) vaccine strain-based vectors were
developed expressing HIV type I (HIV-1) envelope glycoprotein (gp160) from both a …

Here we provide the first report of protection against a vaginal challenge with a highly
virulent simian immunodeficiency virus (SIV) by using a vaccine vector. New poliovirus …

Objective: A live attenuated SIV vaccine strain, termed SIVmac239Δ3 and containing large
deletions in nef, vpr and the negative regulatory element, was previously shown to cause …

Human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) is a
worldwide epidemic, with over 35 million people infected currently. Therefore, the …

We evaluated the ability of an integrase (IN)-defective self-inactivating lentiviral vector
(sinLV) for the delivery of human immunodeficiency virus-1 (HIV-1) envelope sequences in …

Summary Tetherin (BST-2 or CD317) is an interferon-inducible transmembrane protein that
inhibits virus release from infected cells. Whereas HIV-1 Vpu and HIV-2 Env counteract …