Microparticles and nanoparticles as delivery systems for DNA vaccines
Z Cui, RJ Mumper - Critical Reviews™ in Therapeutic Drug …, 2003 - dl.begellhouse.com
ABSTRACT DNA vaccines, also referred to as genetic vaccines, are generating significant
preclinical and clinical interest. It has been proven that the expression of an antigen or …
preclinical and clinical interest. It has been proven that the expression of an antigen or …
Novel anionic microparticles are a potent adjuvant for the induction of cytotoxic T lymphocytes against recombinant p55 gag from HIV-1
J Kazzaz, J Neidleman, M Singh, G Ott… - Journal of controlled …, 2000 - Elsevier
Microparticles with entrapped antigens have recently been shown to possess significant
potential as vaccine delivery systems and adjuvants. However, the potential of …
potential as vaccine delivery systems and adjuvants. However, the potential of …
HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway
SA Swann, M Williams, CM Story, KR Bobbitt, R Fleis… - Virology, 2001 - Elsevier
HIV causes a chronic infection by evading immune eradication. A key element of HIV
immune escape is the HIV-1 Nef protein. Nef causes a reduction in the level of cell surface …
immune escape is the HIV-1 Nef protein. Nef causes a reduction in the level of cell surface …
The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease …
Z Hanna, X Weng, DG Kay, J Poudrier, C Lowell… - Journal of …, 2001 - Am Soc Microbiol
The human immunodeficiency virus type 1 (HIV-1) Nef protein is an important determinant of
AIDS pathogenesis. We have previously reported that HIV-1 Nef is responsible for the …
AIDS pathogenesis. We have previously reported that HIV-1 Nef is responsible for the …
Recombinant rabies virus as potential live-viral vaccines for HIV-1
MJ Schnell, HD Foley, CA Siler… - Proceedings of the …, 2000 - National Acad Sciences
Recombinant, replication-competent rabies virus (RV) vaccine strain-based vectors were
developed expressing HIV type I (HIV-1) envelope glycoprotein (gp160) from both a …
developed expressing HIV type I (HIV-1) envelope glycoprotein (gp160) from both a …
Protection against simian immunodeficiency virus vaginal challenge by using Sabin poliovirus vectors
Here we provide the first report of protection against a vaginal challenge with a highly
virulent simian immunodeficiency virus (SIV) by using a vaccine vector. New poliovirus …
virulent simian immunodeficiency virus (SIV) by using a vaccine vector. New poliovirus …
Live attenuated, nef-deleted SIV is pathogenic in most adult macaques after prolonged observation
R Hofmann-Lehmann, J Vlasak, AL Williams… - Aids, 2003 - journals.lww.com
Objective: A live attenuated SIV vaccine strain, termed SIVmac239Δ3 and containing large
deletions in nef, vpr and the negative regulatory element, was previously shown to cause …
deletions in nef, vpr and the negative regulatory element, was previously shown to cause …
HIV vaccine research: the challenge and the way forward
HB Wang, QH Mo, Z Yang - Journal of immunology research, 2015 - Wiley Online Library
Human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) is a
worldwide epidemic, with over 35 million people infected currently. Therefore, the …
worldwide epidemic, with over 35 million people infected currently. Therefore, the …
Successful immunization with a single injection of non-integrating lentiviral vector
DRM Negri, Z Michelini, S Baroncelli, M Spada… - Molecular therapy, 2007 - cell.com
We evaluated the ability of an integrase (IN)-defective self-inactivating lentiviral vector
(sinLV) for the delivery of human immunodeficiency virus-1 (HIV-1) envelope sequences in …
(sinLV) for the delivery of human immunodeficiency virus-1 (HIV-1) envelope sequences in …
Compensatory changes in the cytoplasmic tail of gp41 confer resistance to tetherin/BST-2 in a pathogenic nef-deleted SIV
Summary Tetherin (BST-2 or CD317) is an interferon-inducible transmembrane protein that
inhibits virus release from infected cells. Whereas HIV-1 Vpu and HIV-2 Env counteract …
inhibits virus release from infected cells. Whereas HIV-1 Vpu and HIV-2 Env counteract …