Long non-coding RNAs (lncRNAs) are diverse transcription products emanating from
thousands of loci in mammalian genomes. Cis-acting lncRNAs, which constitute a …

Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

The mammalian circadian clock involves a transcriptional feed back loop in which CLOCK
and BMAL1 activate the Period and Cryptochrome genes, which then feedback and repress …

Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to
mark the transcription start sites of active genes. Here, we show that H3K4me3 domains that …

The MYC transcription factor is a master regulator of diverse cellular functions and has been
long considered a compelling therapeutic target because of its role in a range of human …

Interaction of pathogens with cells of the immune system results in activation of inflammatory
gene expression. This response, although vital for immune defence, is frequently deleterious …

Cyclin-dependent kinases (CDKs) are proteins pivotal to a wide range of cellular functions,
most importantly cell division and transcription, and their dysregulations have been …

The recognition of modified histones by" reader" proteins constitutes a key mechanism
regulating gene expression in the chromatin context. Compared with the great variety of …

The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

Cancer cells are characterized by aberrant epigenetic landscapes and often exploit
chromatin machinery to activate oncogenic gene expression programs. Recognition of …