The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …

The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …

Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

Abstract Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …

For over 15 years, the peripheral benzodiazepine receptor (PBR), recently named
translocator protein 18 kDa (TSPO) has been studied as a biomarker of reactive gliosis and …

Aims: Microglia are involved in neurodegeneration, are prime targets for anti‐inflammatory
therapy and are potential biomarkers of disease progression. For example, positron …

Mitochondrial dysfunction and the loss of mitophagy, aimed at recycling irreversibly
damaged organelles, contribute to the onset of amyotrophic lateral sclerosis (ALS), a fatal …

The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is expressed in the injured brain. It has become known as an …

VDAC1 is found at the crossroads of metabolic and survival pathways. VDAC1 controls
metabolic cross-talk between mitochondria and the rest of the cell by allowing the influx and …