The role of translocator protein TSPO in hallmarks of glioblastoma

LM Ammer, A Vollmann-Zwerenz, V Ruf, CH Wetzel… - Cancers, 2020 - mdpi.com
Simple Summary The translocator protein (TSPO) has been under extensive investigation as
a specific marker in positron emission tomography (PET) to visualize brain lesions following …

Translocator protein (18 kDa) TSPO: an emerging therapeutic target in neurotrauma

V Papadopoulos, L Lecanu - Experimental neurology, 2009 - Elsevier
Traumatic brain injury (TBI) induces physical, cognitive, and psychosocial deficits that affect
millions of patients. TBI activates numerous cellular mechanisms and molecular cascades …

Voltage-dependent anion channel 1 as an emerging drug target for novel anti-cancer therapeutics

V Shoshan-Barmatz, Y Krelin… - Frontiers in …, 2017 - frontiersin.org
Cancer cells share several properties, high proliferation potential, reprogramed metabolism,
and resistance to apoptotic cues. Acquiring these hallmarks involves changes in key …

The translocator protein

AM Scarf, M Kassiou - Journal of Nuclear Medicine, 2011 - Soc Nuclear Med
The translocator protein (TSPO) is expressed at low levels in the healthy human brain and is
markedly upregulated in response to brain injury and inflammation. This increase in TSPO …

Sex differences in the inflammatory response of primary astrocytes to lipopolysaccharide

M Santos-Galindo, E Acaz-Fonseca, MJ Bellini… - Biology of sex …, 2011 - Springer
Background Numerous neurological and psychiatric disorders show sex differences in
incidence, age of onset, symptomatology or outcome. Astrocytes, one of the glial cell types of …

Current knowledge on the acute regulation of steroidogenesis

V Selvaraj, DM Stocco, BJ Clark - Biology of reproduction, 2018 - academic.oup.com
How rapid induction of steroid hormone biosynthesis occurs in response to trophic hormone
stimulation of steroidogenic cells has been a subject of intensive investigation for …

Translocator protein-mediated pharmacology of cholesterol transport and steroidogenesis

V Papadopoulos, Y Aghazadeh, J Fan… - Molecular and cellular …, 2015 - Elsevier
Steroidogenesis begins with cholesterol transfer into mitochondria through the
transduceosome, a complex composed of cytosolic proteins that include steroidogenesis …

VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis

L Veenman, Y Shandalov, M Gavish - Journal of bioenergetics and …, 2008 - Springer
The voltage dependent anion channel (VDAC), located in the outer mitochondrial
membrane, functions as a major channel allowing passage of small molecules and ions …

TSPO: an evolutionarily conserved protein with elusive functions

F Bonsack, S Sukumari-Ramesh - International journal of molecular …, 2018 - mdpi.com
TSPO (18 kDa translocator protein) was identified decades ago in a search for peripheral
tissue binding sites for benzodiazepines, and was formerly called the peripheral …

The changing landscape in translocator protein (TSPO) function

V Selvaraj, DM Stocco - Trends in Endocrinology & Metabolism, 2015 - cell.com
Translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor
(PBR), is an outer mitochondrial membrane protein. TSPO has been shown to cooperate …