Endozepines and their receptors: structure, functions and pathophysiological significance

MC Tonon, H Vaudry, J Chuquet, F Guillebaud… - Pharmacology & …, 2020 - Elsevier
The existence of specific binding sites for benzodiazepines (BZs) in the brain has prompted
the search for endogenous BZ receptor ligands designated by the generic term …

Molecular imaging of neuroinflammation in Alzheimer's disease and mild cognitive impairment

D Knezevic, R Mizrahi - Progress in Neuro-Psychopharmacology and …, 2018 - Elsevier
Neuroinflammatory changes have been demonstrated to be an important feature of
Alzheimer's disease (AD); however, the exact role of neuroinflammation and its progression …

[HTML][HTML] Structure, gating and interactions of the voltage-dependent anion channel

EE Najbauer, S Becker, K Giller, M Zweckstetter… - European Biophysics …, 2021 - Springer
The voltage-dependent anion channel (VDAC) is one of the most highly abundant proteins
found in the outer mitochondrial membrane, and was one of the earliest discovered. Here …

TSPO exacerbates acute cerebral ischemia/reperfusion injury by inducing autophagy dysfunction

Y Mahemuti, K Kadeer, R Su, A Abula, Y Aili… - Experimental …, 2023 - Elsevier
Autophagy is considered a double-edged sword, with a role in the regulation of the
pathophysiological processes of the central nervous system (CNS) after cerebral ischemia …

Mitochondrial VDAC1: function in cell life and death and a target for cancer therapy

V Shoshan-Barmatz, M Golan - Current medicinal chemistry, 2012 - ingentaconnect.com
Found at the outer mitochondrial membrane, the voltage-dependent anion channel, VDAC,
assumes a crucial position in the cell, serving as the main interface between mitochondrial …

Correlation of ferroptosis and other types of cell death in neurodegenerative diseases

X Dang, X Huan, X Du, X Chen, M Bi, C Yan, Q Jiao… - Neuroscience …, 2022 - Springer
Ferroptosis is defined as an iron-dependent, non-apoptotic cell death pathway, with specific
morphological phenotypes and biochemical changes. There is a growing realization that …

[HTML][HTML] Sex-dependent effects of perinatal inflammation on the brain: implication for neuro-psychiatric disorders

M Ardalan, T Chumak, Z Vexler, C Mallard - International journal of …, 2019 - mdpi.com
Individuals born preterm have higher rates of neurodevelopmental disorders such as
schizophrenia, autistic spectrum, and attention deficit/hyperactivity disorders. These …

[HTML][HTML] Augmented expression of TSPO after intracerebral hemorrhage: a role in inflammation?

F Bonsack, CH Alleyne… - Journal of …, 2016 - Springer
Background Intracerebral hemorrhage (ICH) is a potentially fatal stroke subtype accounting
for 10–15% of all strokes. Despite neurosurgical intervention and supportive care, the 30 …

Structural and functional evolution of the translocator protein (18 kDa)

J Fan, P Lindemann, M GJ Feuilloley… - Current molecular …, 2012 - ingentaconnect.com
Translocator proteins (TSPO) are the products of a family of genes that is evolutionarily
conserved from bacteria to humans and expressed in most mammalian tissues and cells …

TRO40303, a new cardioprotective compound, inhibits mitochondrial permeability transition

S Schaller, S Paradis, GA Ngoh, R Assaly… - … of Pharmacology and …, 2010 - ASPET
3, 5-Seco-4-nor-cholestan-5-one oxime-3-ol (TRO40303) is a new cardioprotective
compound coming from a chemical series identified initially for neuroprotective properties …