PET imaging of the peripheral benzodiazepine receptor: monitoring disease progression and therapy response in neurodegenerative disorders

J Doorduin, EFJ de Vries, RA Dierckx… - Current …, 2008 - ingentaconnect.com
It is important to gain more insight into neurodegenerative diseases, because these
debilitating diseases can not be cured. A common characteristic of many neurological …

The Arabidopsis TSPO‐related protein is a stress and abscisic acid‐regulated, endoplasmic reticulum–Golgi‐localized membrane protein

D Guillaumot, S Guillon, T Déplanque… - The Plant …, 2009 - Wiley Online Library
Summary The Arabidopsis gene At2g47770 encodes a membrane‐bound protein
designated AtTSPO (Arabidopsis thaliana TSPO‐related). AtTSPO is related to the bacterial …

[HTML][HTML] Shedding light on the mitochondrial permeability transition

F Ricchelli, J Šileikytė, P Bernardi - Biochimica et Biophysica Acta (BBA) …, 2011 - Elsevier
The mitochondrial permeability transition is an increase of permeability of the inner
mitochondrial membrane to ions and solutes with an exclusion size of about 1500Da. It is …

Koumine attenuates neuroglia activation and inflammatory response to neuropathic pain

GL Jin, SD He, SM Lin, LM Hong, WQ Chen… - Neural …, 2018 - Wiley Online Library
Despite decades of studies, the currently available drugs largely fail to control neuropathic
pain. Koumine—an alkaloidal constituent derived from the medicinal plant Gelsemium …

Oxidative imbalance and anxiety disorders

R Krolow, DM Arcego, C Noschang… - Current …, 2014 - ingentaconnect.com
The oxidative imbalance appears to have an important role in anxiety development. Studies
in both humans and animals have shown a strong correlation between anxiety and oxidative …

New TSPO crystal structures of mutant and heme-bound forms with altered flexibility, ligand binding, and porphyrin degradation activity

J Liu, C Hiser, F Li, R Hall, RM Garavito… - Biochemistry, 2023 - ACS Publications
The ancient protein TSPO (translocator protein 18kD) is found in all kingdoms and was
originally identified as a binding site of benzodiazepine drugs. Its physiological function …

Axonal regeneration and neuroinflammation: roles for the translocator protein 18 kDa

C Girard, S Liu, D Adams, C Lacroix… - Journal of …, 2012 - Wiley Online Library
After a traumatic injury of the nervous system or in the course of a neurodegenerative
disease, the speed of axonal regeneration and the control of the inflammatory response are …

MIAT, a potent CVD-promoting lncRNA

C Yang, Y Zhang, B Yang - Cellular and Molecular Life Sciences, 2022 - Springer
The initial identification of long non-coding RNA myocardial infarction associated transcript
(MIAT) as a genetic risk factor of myocardial infarction has made this lncRNA (designated as …

A systematic study on drug-response associated genes using baseline gene expressions of the Cancer Cell Line Encyclopedia

X Liu, J Yang, Y Zhang, Y Fang, F Wang, J Wang… - Scientific reports, 2016 - nature.com
We have studied drug-response associated (DRA) gene expressions by applying a systems
biology framework to the Cancer Cell Line Encyclopedia data. More than 4,000 genes are …

Membrane-mediated ligand unbinding of the PK-11195 ligand from TSPO

T Dixon, A Uyar, S Ferguson-Miller, A Dickson - Biophysical journal, 2021 - cell.com
The translocator protein (TSPO), previously known as the peripheral benzodiazepine
receptor, is of longstanding medical interest as both a biomarker for neuroinjury and a …