translocator protein ligand–plga conjugated nanoparticles for 5-fluorouracil delivery to glioma cancer cells
V Laquintana, N Denora, A Lopalco… - Molecular …, 2014 - ACS Publications
Translocator protein 18 kDa (TSPO) is a promising target for molecular imaging and for
targeted drug delivery to tumors overexpressing TSPO. In our previous work, new …
targeted drug delivery to tumors overexpressing TSPO. In our previous work, new …
Classical and novel TSPO ligands for the mitochondrial TSPO can modulate nuclear gene expression: implications for mitochondrial retrograde signaling
N Yasin, L Veenman, S Singh, M Azrad, J Bode… - International Journal of …, 2017 - mdpi.com
It is known that knockdown of the mitochondrial 18 kDa translocator protein (TSPO) as well
as TSPO ligands modulate various functions, including functions related to cancer. To study …
as TSPO ligands modulate various functions, including functions related to cancer. To study …
Targeting of the translocator protein 18 kDa (TSPO): a valuable approach for nuclear and optical imaging of activated microglia
A Trapani, C Palazzo, M de Candia… - Bioconjugate …, 2013 - ACS Publications
The aim of the present review is to give a concise and updated analysis of the imaging tools
for the visualization of activated microglia. After an overview on the important pathologies …
for the visualization of activated microglia. After an overview on the important pathologies …
Translocator protein (18 kDa)(TSPO) as a therapeutic target for anxiety and neurologic disorders
C Nothdurfter, TC Baghai, C Schüle… - European archives of …, 2012 - Springer
Abstract The translocator protein (18kD)(TSPO) plays a crucial role for the synthesis of
neurosteroids by promoting the transport of cholesterol to the inner mitochondrial …
neurosteroids by promoting the transport of cholesterol to the inner mitochondrial …
Differential efficacy of the TSPO ligands etifoxine and XBD-173 in two rodent models of Multiple Sclerosis
B Ravikumar, D Crawford, T Dellovade, A Savinainen… - …, 2016 - Elsevier
Neurosteroids such as progesterone and allopregnanolone have been shown to exert
neuroprotective effects under a variety of pathological or insult conditions, and there is …
neuroprotective effects under a variety of pathological or insult conditions, and there is …
Mitochondrial drugs
PL Toogood - Current opinion in chemical biology, 2008 - Elsevier
Mitochondria are cellular organelles that perform pivotal functions essential for ATP
production, homeostasis, and metabolism. Moreover, mitochondria are integral to a variety …
production, homeostasis, and metabolism. Moreover, mitochondria are integral to a variety …
The TSPO ligands 2-Cl-MGV-1, MGV-1, and PK11195 differentially suppress the inflammatory response of BV-2 microglial cell to LPS
M Azrad, N Zeineh, A Weizman, L Veenman… - International Journal of …, 2019 - mdpi.com
The 18 kDa Translocator Protein (TSPO) is a marker for microglial activation as its
expression is enhanced in activated microglia during neuroinflammation. TSPO ligands can …
expression is enhanced in activated microglia during neuroinflammation. TSPO ligands can …
A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two …
The binding of two radiolabelled analogues (N-(5-[125I] Iodo-2-phenoxyphenyl)-N-(2, 5-
dimethoxybenzyl) acetamide ([125I] desfluoro-DAA1106) and N-(5-[125I] Fluoro-2 …
dimethoxybenzyl) acetamide ([125I] desfluoro-DAA1106) and N-(5-[125I] Fluoro-2 …
TSPO PET imaging: from microglial activation to peripheral sterile inflammatory diseases?
B Largeau, AC Dupont, D Guilloteau… - Contrast media & …, 2017 - Wiley Online Library
Peripheral sterile inflammatory diseases (PSIDs) are a heterogeneous group of disorders
that gathers several chronic insults involving the cardiovascular, respiratory, gastrointestinal …
that gathers several chronic insults involving the cardiovascular, respiratory, gastrointestinal …
Tetrapyrroles as endogenous TSPO ligands in eukaryotes and prokaryotes: Comparisons with synthetic ligands
L Veenman, A Vainshtein, N Yasin, M Azrad… - International journal of …, 2016 - mdpi.com
The 18 kDa translocator protein (TSPO) is highly 0conserved in eukaryotes and prokaryotes.
Since its discovery in 1977, numerous studies established the TSPO's importance for life …
Since its discovery in 1977, numerous studies established the TSPO's importance for life …