GIPR/GLP-1R dual agonist therapies for diabetes and weight loss—chemistry, physiology, and clinical applications

JE Campbell, TD Müller, B Finan, RD DiMarchi… - Cell Metabolism, 2023 - cell.com
The incretin system is an essential metabolic axis that regulates postprandial metabolism.
The two incretin peptides that enable this effect are the glucose-dependent insulinotropic …

What is the pipeline for future medications for obesity?

E Melson, U Ashraf, D Papamargaritis… - International Journal of …, 2024 - nature.com
Obesity is a chronic disease associated with increased risk of obesity-related complications
and mortality. Our better understanding of the weight regulation mechanisms and the role of …

White adipocyte dysfunction and obesity-associated pathologies in humans

CE Hagberg, KL Spalding - Nature Reviews Molecular Cell Biology, 2024 - nature.com
The prevalence of obesity and associated chronic diseases continues to increase
worldwide, negatively impacting on societies and economies. Whereas the association …

A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings

MM Véniant, SC Lu, L Atangan, R Komorowski… - Nature …, 2024 - nature.com
Obesity is a major public health crisis. Multi-specific peptides have emerged as promising
therapeutic strategies for clinical weight loss. Glucagon-like peptide-1 (GLP-1) and glucose …

The role of lifestyle modification with second-generation anti-obesity medications: comparisons, questions, and clinical opportunities

TA Wadden, AM Chao, M Moore, JS Tronieri… - Current obesity …, 2023 - Springer
Abstract Purpose of Review This review examines lifestyle modification for obesity
management with the goal of identifying treatment components that could support the use of …

[HTML][HTML] Obesity and its comorbidities, current treatment options and future perspectives: Challenging bariatric surgery?

S Kloock, CG Ziegler, U Dischinger - Pharmacology & Therapeutics, 2023 - Elsevier
Obesity and its comorbidities, including type 2 diabetes mellitus, cardiovascular disease,
heart failure and non-alcoholic liver disease are a major health and economic burden with …

A revolution in obesity treatment

I Lingvay, S Agarwal - Nature medicine, 2023 - nature.com
A revolution in obesity treatment | Nature Medicine Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

[HTML][HTML] A narrative review of approved and emerging anti-obesity medications

SA Beshir, AA Elnour, A Soorya, AP Mohamed… - Saudi Pharmaceutical …, 2023 - Elsevier
Background Recently, many drugs have been approved for halting overweight and obesity—
few types of research shifted to using Anti-obesity medications (AOM) solely for well-being …

Results from three phase 1 trials of NNC9204-1177, a glucagon/GLP-1 receptor co-agonist: Effects on weight loss and safety in adults with overweight or obesity

MH Friedrichsen, L Endahl, FF Kreiner, R Goldwater… - Molecular …, 2023 - Elsevier
Objective Glucagon/glucagon-like peptide-1 (GLP-1) receptor co-agonists may provide
greater weight loss than agonists targeting the GLP-1 receptor alone. We report results from …

Glucagon and GLP-1 receptor dual agonist survodutide for obesity: a randomised, double-blind, placebo-controlled, dose-finding phase 2 trial

CW le Roux, O Steen, KJ Lucas, E Startseva… - The Lancet Diabetes & …, 2024 - thelancet.com
Background Obesity is a widespread and chronic condition that requires long-term
management; research into additional targets to improve treatment outcomes remains a …