There is growing evidence that coronavirus disease 2019 (COVID-19) can lead to a
dysregulation of the immune system with the development of autoimmune phenomena. The …

Osteoarthritis (OA) remains the most challenging arthritic disorder, with a high burden of
disease and no available disease-modifying treatments. Symptomatic early-stage OA of the …

Objective To develop and validate updated classification criteria for giant cell arteritis (GCA).
Methods Patients with vasculitis or comparator diseases were recruited into an international …

Sjögren's syndrome is a chronic autoimmune disease characterized by ocular and oral
dryness resulting from lacrimal and salivary gland dysfunction. Besides, a variety of systemic …

Key Clinical Points Primary Sjögren's Syndrome A diagnosis of primary Sjögren's syndrome
is often made on the basis of a classic triad of symptoms: dryness of the mouth and eyes …

In primary Sjögren syndrome (pSS), the function of the salivary glands is often considerably
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …

The therapeutic management of Sjögren syndrome (SjS) has not changed substantially in
recent decades: treatment decisions remain challenging in clinical practice, without a …

The indirect immunofluorescence assay (IIFA) on HEp-2 cells is widely used for detection of
antinuclear antibodies (ANA). The dichotomous outcome, negative or positive, is integrated …

Background & Aims Disease activity and severity of eosinophilic esophagitis (EoE) dictate
therapeutic options and management, but the decision-making process for determining …

In primary Sjögren syndrome (pSS), chronic inflammation of exocrine glands results in tissue
destruction and sicca symptoms, primarily of the mouth and eyes. Fatigue, arthralgia and …