Non-alcoholic steatohepatitis (NASH) represents a global health concern. It is characterised
by fatty liver, hepatocyte cell death and inflammation, which are associated with lipotoxicity …

Metabolic associated fatty liver disease (MAFLD) is one of the most common causes of
chronic liver disease worldwide. To date, there is no FDA-approved treatment, so there is an …

Gut health is important for nutrition absorption, reproduction, and lactation in perinatal and
early weaned mammals. Although melatonin functions in maintaining circadian rhythms and …

Ferroptosis, an iron-dependent cell death form, has recently been observed in the
development of non-alcoholic fatty liver disease (NAFLD). Melatonin (Mel) shows potential …

The circadian clock acts a pivotal part in human daily physiology and metabolism. Excess
alcohol consumption disturbs the circadian rhythm of several metabolism-related genes of …

Objective Fine particulate matter (PM2. 5) is a source of pollution worldwide, that causes
inflammation and liver fibrosis. Melatonin, as the predominant hormone secreted by the …

Iron overload as a highly risk factor, can be found in almost all human chronic and common
diseases. Iron chelators are often used to treat iron overload; however, patient adherence to …

Ferroptosis, a novel type of cell death mediated by the iron‐dependent lipid peroxidation,
contributes to the pathogenesis of the intervertebral disc degeneration (IDD). Increasing …

Nonalcoholic fatty liver disease (NAFLD) has become an increasingly common disease in
Western countries and has become the major cause of liver cirrhosis or hepatocellular …

Melatonin (MLT) is a hormonal substance reported with various pharmacological activities.
Based on its effects of neuroprotection and metabolic regulation, the aim of the present study …