Drug-resistant tuberculosis (DR-TB) remains a global crisis due to the increasing incidence
of drug-resistant forms of the disease, gaps in detection and prevention, models of care, and …

Human infection with Mycobacterium tuberculosis can progress to active disease, be
contained as latent infection, or be eradicated by the host response. Tuberculosis …

Rationale Globally there are approximately 9 million new active tuberculosis cases and 1.4
million deaths annually. Effective antituberculosis treatment monitoring is difficult as there …

New drugs, vaccines, and other therapies will be required to realise the goal of global
tuberculosis elimination or control. This Review covers the important role biomarkers can …

Tuberculosis (TB) is a health threat to the global population. Anti-TB drugs and vaccines are
key approaches for TB prevention and control. TB animal models are basic tools for …

The past 10 years have seen the most rapid growth in new diagnostics for Mtb in over a
century. Although these tests offer improvements in the ability to detect Mtb, drug-resistant …

Background Sputum Mycobacterium tuberculosis (Mtb) culture is commonly used to assess
response to antibiotic treatment in individuals with pulmonary tuberculosis (TB). Such …

Background The successful treatment of tuberculosis (TB) requires long-term multidrug
chemotherapy. Clinical trials to evaluate new drugs and regimens for TB treatment are …

Most people infected with Mycobacterium tuberculosis, the causative agent of tuberculosis
(TB) actually maintain a strong immune response and are able to control bacterial growth …

Pyrazinamide (PZA) is one of the first line antibiotics used for the treatment of tuberculosis
(TB). In the present study, we have used in vitro and in vivo systems to investigate whether …