Most head and neck cancers are derived from the mucosal epithelium in the oral cavity,
pharynx and larynx and are known collectively as head and neck squamous cell carcinoma …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

There is robust epidemiological evidence for the beneficial effects of broccoli consumption
on health, many of them clearly mediated by the isothiocyanate sulforaphane. Present in the …

There is substantial and promising evidence on the health benefits of consuming broccoli
and other cruciferous vegetables. The most important compound in broccoli, glucoraphanin …

Background Since the re-discovery of sulforaphane in 1992 and the recognition of the
bioactivity of this phytochemical, many studies have examined its mode of action in cells …

Isothicyanates present in cruciferous vegetables are known to exhibit chemoprevention by
various mechanisms. Presently, there is growing evidence that a phytochemical compound …

Background: Burnout is a chronic stress-related syndrome with the three dimensions of
exhaustion, cynicism, and inefficacy. Musculoskeletal disorders (MSDs) are defined as a …

Despite the progress that has occurred in recent years in the development of therapies to
treat painful and inflammatory diseases, there is still a need for effective and potent …

Nrf2 is a master transcriptional regulator of antioxidant and cytoprotective pathways.
Currently in its third decade, research on Nrf2 has expanded to encompass not only basic …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) plays a
critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the …