Hypercholesterolaemia leads to cholesterol accumulation in macrophages and other
immune cells, which promotes inflammatory responses, including augmentation of Toll-like …

Atherosclerosis can be regarded as a chronic inflammatory state, in which macrophages
play different and important roles. Phagocytic proinflammatory cells populate growing …

Plasma levels of high-density lipoprotein (HDL) inversely correlate with the incidence of
cardiovascular diseases (CVD). The causal relationship between plasma HDL-cholesterol …

A wide variety of cell populations, including both immune and endothelial cells, participate in
the pathogenesis of atherosclerosis. Among these groups, macrophages deserve special …

Atherosclerosis, the pathological basis of most cardiovascular disease (CVD), is closely
associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is …

Atherosclerosis is characterized by chronic low grade inflammation of arteries that results in
the development of lipid dense plaques. Chronic inflammation induced by Western-type diet …

Atherosclerosis is an inflammatory disease linked to elevated blood cholesterol
concentrations. Despite ongoing advances in the prevention and treatment of …

The response of immune cells to pathogens is often associated with changes in the flux
through basic metabolic pathways. Indeed, in many cases changes in metabolism appear to …

A considerable volume of research over the last decade has focused on understanding the
fundamental mechanisms for the progression of atherosclerosis—the underlying cause for …

Aims Neutrophil extracellular trap formation (NETosis) increases atherosclerotic plaque
vulnerability and athero-thrombosis. However, mechanisms promoting NETosis during …