Neoplastic expansion of myeloid cells is associated with specific genetic changes that lead
to chronic activation of signaling pathways, as well as altered metabolism. It has become …

The mammalian target of rapamycin (mTOR) is one target of BCR‐ABL fusion gene of
chronic myeloid leukemia (CML). Moreover, it drives a compensatory route to Imatinib …

Peripheral T-cell lymphomas not otherwise specified (PTCL/NOS) are very aggressive
tumors characterized by consistent aberrant expression of platelet-derived growth factor …

Protein kinases have been discussed as promising druggable targets in various parasitic
helminths. New drugs are also needed for control of fascioliasis, a food-borne trematode …

Here we demonstrated that the 'loss of function'of not‐rearranged c‐ABL in chronic myeloid
leukemia (CML) is promoted by its cytoplasmic compartmentalization bound to 14‐3‐3 …

Slug, a Snail-related zinc-finger transcription factor implicated in the increased motility of
mesenchymal cells during embryonic development and progression of cancer cells towards …

Constitutive tyrosine kinase (TK) activity of p210 BCR-ABL fusion protein of chronic myeloid
leukemia (CML) usurps physiological functions of normal p145 c-ABL protein. Accordingly …

Background Selective inhibition of the BCR-ABL tyrosine kinase by RNA interference has
been demonstrated in leukemic cells. We, therefore, evaluated specific BCR-ABL small …

Background SPARC is a matricellular glycoprotein with growth-inhibitory and antiangiogenic
activity in some cell types. The study of this protein in hematopoietic malignancies led to …

The BCR‐ABL fusion gene, originating from the balanced (9; 22) translocation, is the
molecular hallmark and the causative event of chronic myeloid leukaemia (CML). The …