From multi-omics approaches to personalized medicine in myocardial infarction
Myocardial infarction (MI) is a prevalent cardiovascular disease characterized by myocardial
necrosis resulting from coronary artery ischemia and hypoxia, which can lead to severe …
necrosis resulting from coronary artery ischemia and hypoxia, which can lead to severe …
Analysis of cardiac single-cell RNA-sequencing data can be improved by the use of artificial-intelligence-based tools
Single-cell RNA sequencing (scRNAseq) enables researchers to identify and characterize
populations and subpopulations of different cell types in hearts recovering from myocardial …
populations and subpopulations of different cell types in hearts recovering from myocardial …
[HTML][HTML] Promoting cardiomyocyte proliferation for myocardial regeneration in large mammals
From molecular and cellular perspectives, heart failure is caused by the loss of
cardiomyocytes—the fundamental contractile units of the heart. Because mammalian …
cardiomyocytes—the fundamental contractile units of the heart. Because mammalian …
WINNER: A network biology tool for biomolecular characterization and prioritization
Background and contribution In network biology, molecular functions can be characterized
by network-based inference, or “guilt-by-associations.” PageRank-like tools have been …
by network-based inference, or “guilt-by-associations.” PageRank-like tools have been …
[HTML][HTML] Cell-cycle–specific autoencoding improves cluster analysis of cycling cardiomyocytes
Background Our previous analyses of cardiomyocyte single-nucleus RNA sequencing
(snRNAseq) data from the hearts of fetal pigs and pigs that underwent apical resection …
(snRNAseq) data from the hearts of fetal pigs and pigs that underwent apical resection …
Single-cell RNA sequencing analysis identifies one subpopulation of endothelial cells that proliferates and another that undergoes the endothelial-mesenchymal …
Background: In our previous work, we demonstrated that when newborn pigs undergo apical
resection (AR) on postnatal day 1 (P1), the animals' hearts were completely recover from a …
resection (AR) on postnatal day 1 (P1), the animals' hearts were completely recover from a …
Impact of Arthroplasty Surgery on the Local Immune Composition of the Knee Joint and Implications for the Periprosthetic Joint Infection
KH Cichos - 2023 - digitalcommons.library.uab.edu
The overall risk of infection after total knee arthroplasty (TKA) has not improved over the past
20 years, remaining 10-40 times greater than the risk of infection of a native knee. Despite …
20 years, remaining 10-40 times greater than the risk of infection of a native knee. Despite …