Fatty acid-binding proteins (FABPs) bind and internalize long-chain fatty acids, controlling
lipid dynamics. Recent studies have proposed the involvement of FABPs, particularly …

Autophagy is an evolutionarily conserved process that contributes to maintain cell
homeostasis. Although it is strongly regulated by many extracellular factors, induction of …

Stress granules (SGs) assemble under stress-induced conditions that inhibit protein
synthesis, including phosphorylation of eIF2α, inhibition of the RNA helicase eIF4a proteins …

Chronic hypoxia exacerbates proliferation of pulmonary arterial smooth muscle cells
(PASMC), thereby reducing the lumen of pulmonary arteries. This leads to poor blood …

Autophagy helps maintain energy homeostasis and protect cells from stress effects by
selectively removing misfolded/polyubiquitylated proteins, lipids, and damaged …

The clinical use of anthracyclines in cancer therapy is limited by dose-dependent
cardiotoxicity that involves cardiomyocyte injury and death. We have tested the hypothesis …

Tetrapyrroles are involved in light harvesting and light perception, electron-transfer
reactions, and as co-factors for key enzymes and sensory proteins. Under conditions in …

Intracellular redox dyshomeostasis promoted by tumor microenvironment (TME) modulation
has become an appealing therapeutic target for cancer management. Herein, a dual …

The pathogenic mechanisms of Alzheimer's Disease (AD) involve the deposition of
abnormally misfolded proteins, amyloid β protein (Aβ) and tau protein. Aβ comprises senile …

Nutrient-limiting conditions are common during cancer development. The coordination of
cellular glucose levels and cell survival is a fundamental question in cell biology and has not …