Neural tube closure has been studied for many decades, across a range of vertebrates, as a
paradigm of embryonic morphogenesis. Neurulation is of particular interest in view of the …

Neural tube defects (NTDs), including spina bifida and anencephaly, are severe birth
defects of the central nervous system that originate during embryonic development when the …

Neural tube defects (NTDs) are severe congenital malformations affecting 1 in every 1000
pregnancies.'Open'NTDs result from failure of primary neurulation as seen in anencephaly …

Tissue fusion events during embryonic development are crucial for the correct formation and
function of many organs and tissues, including the heart, neural tube, eyes, face and body …

Orofacial clefts, including cleft lip and palate (CL/P) and neural tube defects (NTDs) are
among the most common congenital anomalies, but knowledge of the genetic basis of these …

The mammalian homologs of the D. melanogaster Grainyhead gene, Grainyhead-like 1–3
(GRHL1, GRHL2 and GRHL3), are transcription factors implicated in wound healing …

The molecular requirements for neural tube closure are complex. This is illustrated by the
occurrence of neural tube defects (NTDs) in many genetic mouse mutants, which implicate a …

Lack or excess expression of the surface ectoderm-expressed transcription factor
Grainyhead-like2 (Grhl2), each prevent spinal neural tube closure. Here we investigate the …

Grainyhead-like (GRHL) factors are essential, highly conserved transcription factors (TFs)
that regulate processes common to both natural cellular behaviours during embryogenesis …

Much of what we know about the role of epigenetics in the determination of phenotype has
come from studies of inbred mice. Some unusual expression patterns arising from …