Abstract Hypoxia‑ischemia (H‑I) is frequently observed in perinatal asphyxia and other
diseases. It can lead to serious cardiac injury, cerebral damage, neurological disability and …

Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …

Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Atherosclerosis is a multifocal alteration of the vascular wall of medium and large arteries
characterized by a local accumulation of cholesterol and non-resolving inflammation …

The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues,
and organs. Under extended exposure to reduced oxygen levels, cells are able to survive …

Insufficient vessel growth associated with ischemia remains an unresolved issue in vascular
medicine. Mesenchymal stem cells (MSCs) have been shown to promote angiogenesis via a …

The critical role of the vasculature and its repair in neurological disease states is beginning
to emerge particularly for stroke, dementia, epilepsy, Parkinson's disease, tumors and …

With growing interest in cancer therapeutics, anti-angiogenic therapy has received
considerable attention and is widely administered in several types of human cancers …

Antiangiogenic drugs targeting the VEGF pathway have slowed metastatic disease
progression in some patients, leading to progression-free survival (PFS) and overall survival …