Endoplasmic reticulum stress and homeostasis in reproductive physiology and pathology
The endoplasmic reticulum (ER), comprises 60% of the total cell membrane and interacts
directly or indirectly with several cell organelles ie, Golgi bodies, mitochondria and …
directly or indirectly with several cell organelles ie, Golgi bodies, mitochondria and …
Immunoendocrine dysregulation during gestational diabetes mellitus: The central role of the placenta
A Olmos-Ortiz, P Flores-Espinosa, L Díaz… - International Journal of …, 2021 - mdpi.com
Gestational Diabetes Mellitus (GDM) is a transitory metabolic condition caused by
dysregulation triggered by intolerance to carbohydrates, dysfunction of beta-pancreatic and …
dysregulation triggered by intolerance to carbohydrates, dysfunction of beta-pancreatic and …
Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity
R Villalobos-Labra, M Subiabre, F Toledo… - Molecular aspects of …, 2019 - Elsevier
Diabesity is an abnormal metabolic condition shown by patients with obesity that develop
type 2 diabetes mellitus. Patients with diabesity present with insulin resistance, reduced …
type 2 diabetes mellitus. Patients with diabesity present with insulin resistance, reduced …
[HTML][HTML] Endothelial dysfunction in pregnancy metabolic disorders
In recent years, the vascular endothelium has gained attention as a key player in the
initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ …
initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ …
Pharmacological targeting of adenosine receptor signaling
Adenosine receptor signaling plays important roles in normal physiology, but is also known
to modulate the development or progression of several different diseases. The design of …
to modulate the development or progression of several different diseases. The design of …
Akt/mTOR role in human foetoplacental vascular insulin resistance in diseases of pregnancy
R Villalobos-Labra, L Silva, M Subiabre… - Journal of Diabetes …, 2017 - Wiley Online Library
Insulin resistance is characteristic of pregnancies where the mother shows metabolic
alterations, such as preeclampsia (PE) and gestational diabetes mellitus (GDM), or …
alterations, such as preeclampsia (PE) and gestational diabetes mellitus (GDM), or …
Pro-angiogenic role of insulin: from physiology to pathology
CA Escudero, K Herlitz, F Troncoso, K Guevara… - Frontiers in …, 2017 - frontiersin.org
The underlying molecular mechanisms involve in the regulation of the angiogenic process
by insulin are not well understood. In this review article, we aim to describe the role of insulin …
by insulin are not well understood. In this review article, we aim to describe the role of insulin …
Insulin/adenosine axis linked signalling
Regulation of blood flow depends on systemic and local release of vasoactive molecules
such as insulin and adenosine. These molecules cause vasodilation by activation of plasma …
such as insulin and adenosine. These molecules cause vasodilation by activation of plasma …
Defective insulin receptor signaling in patients with gestational diabetes is related to dysregulated miR-140 which can be improved by naringenin
C Zhao, C Zhao, H Zhao - The International Journal of Biochemistry & Cell …, 2020 - Elsevier
Gestational diabetes (GDM) affects about 20% of pregnancies globally. Defective insulin
receptor (IR) signaling has been found in the placenta from patients with GDM, but the …
receptor (IR) signaling has been found in the placenta from patients with GDM, but the …
Adenosine and preeclampsia
Adenosine is an endogenous nucleoside with pleiotropic effects in different physiological
processes including circulation, renal blood flow, immune function, or glucose homeostasis …
processes including circulation, renal blood flow, immune function, or glucose homeostasis …