Human T cell leukemia virus type 1: persistence and pathogenesis

CRM Bangham - Annual review of immunology, 2018 - annualreviews.org
Human T cell leukemia virus type 1 (HTLV-1), also known as human T lymphotropic virus
type 1, was the first exogenous human retrovirus discovered. Unlike the distantly related …

[HTML][HTML] Cytokine networks dysregulation during HTLV-1 infection and associated diseases

N Futsch, G Prates, R Mahieux, J Casseb, H Dutartre - Viruses, 2018 - mdpi.com
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of a neural chronic
inflammation, called HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) …

Depletion of Blautia Species in the Microbiota of Obese Children Relates to Intestinal Inflammation and Metabolic Phenotype Worsening

A Benítez-Páez, EM Gómez del Pugar, I López-Almela… - Msystems, 2020 - Am Soc Microbiol
Cross-sectional studies conducted with obese and control subjects have suggested
associations between gut microbiota alterations and obesity, but the links with specific …

[HTML][HTML] Comprehensive analysis of TCR-β repertoire in patients with neurological immune-mediated disorders

AP Alves Sousa, KR Johnson, J Ohayon, J Zhu… - Scientific reports, 2019 - nature.com
In this study we characterized the TCR repertoire profiles in patients with chronic
progressive inflammatory neurological disorders including HAM/TSP, associated with …

[HTML][HTML] Pathogenesis of HTLV-1 infection and progression biomarkers: An overview

C Brites, MF Grassi, JAS Quaresma, R Ishak… - Brazilian Journal of …, 2021 - SciELO Brasil
Infection by human T-cell lymphotropic virus type 1 (HTLV-1) occurs in lymphocytes, which
travel throughout the body, thus affecting several target organs and causing varied clinical …

[HTML][HTML] Lessons from the cerebrospinal fluid analysis of HTLV-1-infected individuals: biomarkers of inflammation for HAM/TSP development

NL Freitas, YCP Gomes, FS Souza, RC Torres… - Viruses, 2022 - mdpi.com
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a
neurodegenerative disease that leads to motor impairment due to a chronic inflammatory …

[HTML][HTML] Baseline IFN-γ and IL-10 expression in PBMCs could predict response to PD-1 checkpoint inhibitors in advanced melanoma patients

EF Giunta, G Barra, V De Falco, G Argenziano… - Scientific Reports, 2020 - nature.com
Anti-PD-1 antibodies revolutionized the treatment of advanced melanoma patients.
However, one out of three do not respond to this therapy, with an overall poor prognosis …

[HTML][HTML] Switching and loss of cellular cytokine producing capacity characterize in vivo viral infection and malignant transformation in human T- lymphotropic virus …

H Kagdi, MA Demontis, JC Ramos, GP Taylor - PLoS pathogens, 2018 - journals.plos.org
Adult T-cell leukaemia/lymphoma (ATL) arises from chronic non-malignant human T
lymphotropic virus type-1 (HTLV-1) infection which is characterized by high plasma pro …

[HTML][HTML] Early effects of HTLV-1 infection on the activation, exhaustion, and differentiation of T-Cells in humanized NSG mice

OM Espíndola, E Siteur-van Rijnstra, E Frankin… - Cells, 2021 - mdpi.com
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy of CD4+ T-cells
associated with HTLV-1 infection. In this study, we used the model of immunodeficient NSG …

Novel insights into human T‐lymphotropic virus type‐1 (HTLV‐1) pathogenesis‐host interactions in the manifestation of HTLV‐1‐associated myelopathy/tropical …

S Ahmadi Ghezeldasht, A Mosavat… - Reviews in Medical …, 2024 - Wiley Online Library
Human T‐lymphotropic virus type‐1 (HTLV‐1) was the first discovered human oncogenic
retrovirus, the etiological agent of two serious diseases have been identified as adult T‐cell …