This review is aimed to provide a concise yet extensive survey of key short bioactive peptide
sequences for a range of applications ranging from biomaterials development to peptides …

Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and
synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central …

Morphine is an alkaloid from the opium poppy used to treat pain. The potentially lethal side
effects of morphine and related opioids—which include fatal respiratory depression—are …

Abstract µ-Opioid peptide receptor (MOPR) stimulation alters respiration, analgesia and
reward behaviour, and can induce substance abuse and overdose,–. Despite its evident …

Pain thresholds are, in part, set as a function of emotional and internal states by descending
modulation of nociceptive transmission in the spinal cord. Neurons of the rostral …

A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

Opiates are among the oldest medications available to manage a number of medical
problems. Although pain is the current focus, early use initially focused upon the treatment of …

We define the chemoconnectome (CCT) as the entire set of neurotransmitters,
neuromodulators, neuropeptides, and their receptors underlying chemotransmission in an …

A model of the neuropsychology of anxiety is proposed. The model is based in the first
instance upon an analysis of the behavioural effects of the antianxiety drugs …

Prolactin is a protein hormone of the anterior pituitary gland that was originally named for its
ability to promote lactation in response to the suckling stimulus of hungry young mammals …